ubr-1

Caenorhabditis elegans

Enables ubiquitin conjugating enzyme binding activity. Involved in negative regulation of glutamate metabolic process and regulation of backward locomotion. Predicted to be located in cytoplasm. Predicted to be part of ubiquitin ligase complex. Expressed in body wall musculature; lateral ganglion; pharynx; and seam cell. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome and atherosclerosis. Is an ortholog of human UBR1 (ubiquitin protein ligase E3 component n-recognin 1) and UBR2 (ubiquitin protein ligase E3 component n-recognin 2).

Gpt

Mus musculus

PHENOTYPE: Electrophoretic variants are detected in C57BL/6, BALB/c and DBA/2 (a allele); in MA/J and NZB/Bl (b allele). M. m. molossinus and M. m. castaneus have either the b or c allele. In liver, GPT1 activity rises dramatically at 12-19 days to adult levels. [provided by MGI curators]

Asmt

Mus musculus

PHENOTYPE: Pineal melatonin synthesis requires enzymes encoded by Asmt and Aanat. C57BL/6, BALB/c, AKR/J, NZB/Bl, IS/Cam, and CAST/Ei carry the a allele of Asmt and lack melatonin. SK/Cam, SF/Cam, PERU, and FDS carry the b allele and have normal melatonin levels. [provided by MGI curators]

Ubr1

Rattus norvegicus

Predicted to enable L-leucine binding activity and ubiquitin protein ligase activity. Predicted to be involved in cellular response to L-leucine; negative regulation of TOR signaling; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of proteasome complex and ubiquitin ligase complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome and cardiovascular system disease. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.