Ahdc1 [Search on AGR]
Homo sapiens This gene encodes a protein containing two AT-hooks, which likely function in DNA binding. Mutations in this gene were found in individuals with Xia-Gibbs syndrome. [provided by RefSeq, Jun 2014]
Ahdc1 [Search on AGR]
Mus musculus PHENOTYPE: Mosaic mice with CRISPR cutting on at least one allele exhibit developmental patterning defects affecting craniofacial structure, abdominal wall closure and epidermal stratification that mirror phenotypes seen in Xia-Gibbs syndrome. [provided by MGI curators]
Ahdc1 [Search on AGR]
Rattus norvegicus Predicted to enable DNA-binding transcription factor activity and promoter-enhancer loop anchoring activity. Predicted to be involved in mesoderm formation and skin morphogenesis. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Xia-Gibbs Syndrome. Orthologous to human AHDC1 (AT-hook DNA binding motif containing 1); INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.