lin-15

Caenorhabditis elegans

ldh-1

Caenorhabditis elegans

Enables L-lactate dehydrogenase activity. Predicted to be involved in lactate metabolic process and pyruvate metabolic process. Predicted to be located in mitochondrion. Expressed in tail. Is an ortholog of several human genes including LDHA (lactate dehydrogenase A); LDHB (lactate dehydrogenase B); and LDHC (lactate dehydrogenase C).

taap-1

Caenorhabditis elegans

Predicted to be located in membrane. Is an ortholog of human FAM162A (family with sequence similarity 162 member A) and FAM162B (family with sequence similarity 162 member B).

srp-8

Caenorhabditis elegans

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); autoimmune disease (multiple); and lung disease (multiple). Is an ortholog of several human genes including SERPINB1 (serpin family B member 1); SERPINB8 (serpin family B member 8); and SERPINB9 (serpin family B member 9).

spp-6

Caenorhabditis elegans

Enriched in ALM; PLM; body wall muscle cell; and intestine based on tiling array; microarray; and RNA-seq studies. Is affected by several genes including etr-1; rsr-2; and csr-1 based on microarray; tiling array; and RNA-seq studies. Is affected by eleven chemicals including methylmercuric chloride; stavudine; and Psoralens based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Saposin B type domain; Saposin B type, region 2; Saposin-like type B, region 2; and Saposin-like.

C09D4.4

Caenorhabditis elegans

Predicted to be involved in cellular lipid metabolic process. Is an ortholog of human FAM135A (family with sequence similarity 135 member A) and FAM135B (family with sequence similarity 135 member B).

dyf-11

Caenorhabditis elegans

Predicted to enable microtubule binding activity. Involved in several processes, including cilium organization; dauer entry; and hyperosmotic response. Located in axoneme and ciliary basal body. Part of intraciliary transport particle B. Expressed in ciliated neurons and sensory neurons. Human ortholog(s) of this gene implicated in Senior-Loken syndrome. Is an ortholog of human TRAF3IP1 (TRAF3 interacting protein 1).

cyn-5

Caenorhabditis elegans

Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in cytoplasm. Expressed in intestine. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 9. Is an ortholog of human PPIB (peptidylprolyl isomerase B).

lin-8

Caenorhabditis elegans

Involved in negative regulation of vulval development. Located in nucleus. Expressed in germ line; head neurons; and oocyte.

unc-15

Caenorhabditis elegans

Enables SH3 domain binding activity; cytoskeletal protein binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of ovulation; positive regulation of sarcomere organization; and skeletal muscle myosin thick filament assembly. Located in A band and myosin filament. Expressed in alimentary muscle; body wall musculature; gonad; vulval muscle; and in male. Is an ortholog of human MYH16 (myosin heavy chain 16).