puf-8

Caenorhabditis elegans

Enables mRNA 3'-UTR binding activity. Involved in male meiotic nuclear division; negative regulation of MAPK cascade; and spermatogenesis. Located in P granule and nuclear periphery. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P8.p hermaphrodite; germ line; and vulva. Used to study obesity. Human ortholog(s) of this gene implicated in cerebellar ataxia type 47. Is an ortholog of human PUM1 (pumilio RNA binding family member 1) and PUM2 (pumilio RNA binding family member 2).

mpdu-1

Caenorhabditis elegans

Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation If. Is an ortholog of human MPDU1 (mannose-P-dolichol utilization defect 1).

Y48E1B.17

Caenorhabditis elegans

Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Is an ortholog of human PIGP (phosphatidylinositol glycan anchor biosynthesis class P).

T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

sop-3

Caenorhabditis elegans

Predicted to be located in nucleus. Expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; P5.p hermaphrodite; P8.p hermaphrodite; and neurons.

edc-3

Caenorhabditis elegans

Predicted to enable mRNA binding activity. Predicted to be involved in P-body assembly and deadenylation-independent decapping of nuclear-transcribed mRNA. Predicted to be located in P-body. Expressed in hypodermal cell; intestinal cell; neurons; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 50. Is an ortholog of human EDC3 (enhancer of mRNA decapping 3).

meg-4

Caenorhabditis elegans

Involved in P granule assembly; germ cell proliferation; and organelle localization. Located in P granule. Expressed in pharynx.

adh-5

Caenorhabditis elegans

Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including AMED syndrome; alcohol dependence; and late onset Parkinson's disease. Is an ortholog of human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide).

popl-1

Caenorhabditis elegans

Predicted to enable RNA binding activity and hydrolase activity. Predicted to be involved in tRNA processing. Predicted to be located in nucleolus. Predicted to be part of nucleolar ribonuclease P complex and ribonuclease MRP complex. Human ortholog(s) of this gene implicated in anauxetic dysplasia 2. Is an ortholog of human POP1 (POP1 homolog, ribonuclease P/MRP subunit).

pid-5

Caenorhabditis elegans

Predicted to enable aminopeptidase activity. Predicted to be involved in regulatory ncRNA-mediated gene silencing. Predicted to be located in P-body and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in acquired angioedema. Is an ortholog of human XPNPEP1 (X-prolyl aminopeptidase 1).