Y48A5A.1

Caenorhabditis elegans

Predicted to enable unfolded protein binding activity. Predicted to be involved in box H/ACA snoRNP assembly. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in dystonia. Is an ortholog of human SHQ1 (SHQ1, H/ACA ribonucleoprotein assembly factor).

catp-3

Caenorhabditis elegans

Predicted to enable P-type sodium:potassium-exchanging transporter activity. Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in stomach cancer. Is an ortholog of human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit) and ATP4A (ATPase H+/K+ transporting subunit alpha).

Y48A6B.3

Caenorhabditis elegans

Predicted to enable box H/ACA snoRNA binding activity. Predicted to be involved in rRNA pseudouridine synthesis and snRNA pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Is an ortholog of human NHP2 (NHP2 ribonucleoprotein).

catp-2

Caenorhabditis elegans

Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in stomach cancer. Is an ortholog of human ATP12A (ATPase H+/K+ transporting non-gastric alpha2 subunit) and ATP4A (ATPase H+/K+ transporting subunit alpha).

K02E7.10

Caenorhabditis elegans

Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Down syndrome; Huntington's disease; and cerebrovascular disease (multiple). Is an ortholog of human CTSH (cathepsin H); CTSK (cathepsin K); and CTSS (cathepsin S).

chl-1

Caenorhabditis elegans

Predicted to enable DNA helicase activity. Involved in positive regulation of cell population proliferation. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Warsaw breakage syndrome. Is an ortholog of human DDX11 (DEAD/H-box helicase 11).

F25H8.2

Caenorhabditis elegans

Predicted to enable RNA binding activity. Predicted to be involved in box H/ACA snoRNP assembly and ribosome biogenesis. Located in nucleus. Human ortholog(s) of this gene implicated in melanoma. Is an ortholog of human NAF1 (nuclear assembly factor 1 ribonucleoprotein).

dkc-1

Caenorhabditis elegans

Predicted to enable pseudouridine synthase activity. Predicted to be involved in box H/ACA sno(s)RNA 3'-end processing and pseudouridine synthesis. Predicted to be located in nucleolus. Predicted to be part of box H/ACA snoRNP complex. Human ortholog(s) of this gene implicated in X-linked dyskeratosis congenita and aplastic anemia. Is an ortholog of human DKC1 (dyskerin pseudouridine synthase 1).

T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

gcsh-2

Caenorhabditis elegans

Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be located in mitochondrion. Predicted to be part of glycine cleavage complex. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and multiple mitochondrial dysfunctions syndrome. Is an ortholog of human GCSH (glycine cleavage system protein H).