TBX5-AS1

Homo sapiens

ASSOCIATED WITH Holt-Oram syndrome; INTERACTS WITH benzo[a]pyrene; permethrin; sunitinib

tbx-9

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis. Located in nucleus. Expressed in several structures, including ABarpa; Eal; Ear; Epl; and Epr. Human ortholog(s) of this gene implicated in several diseases, including Holt-Oram syndrome; asthma, nasal polyps, and aspirin intolerance; and malaria. Is an ortholog of several human genes including EOMES (eomesodermin); TBR1 (T-box brain transcription factor 1); and TBX5 (T-box transcription factor 5).

tbx-8

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis. Located in nucleus. Expressed in several structures, including Eal; Ear; Epl; Epr; and intestine. Human ortholog(s) of this gene implicated in several diseases, including Holt-Oram syndrome; asthma, nasal polyps, and aspirin intolerance; and malaria. Is an ortholog of several human genes including EOMES (eomesodermin); TBR1 (T-box brain transcription factor 1); and TBX5 (T-box transcription factor 5).

sem-4

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cell differentiation; regulation of gene expression; and response to oxidative stress. Located in nucleus. Expressed in several structures, including HSN; M lineage cell; rectal epithelial cell; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Duane retraction syndrome; Duane-radial ray syndrome; and Holt-Oram syndrome. Is an ortholog of human SALL1 (spalt like transcription factor 1) and SALL3 (spalt like transcription factor 3).

Tbx5

Rattus norvegicus

Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in response to aldosterone and transdifferentiation. Predicted to be located in cytoplasm. Predicted to be part of chromatin and transcription regulator complex. Predicted to be active in nucleus. Used to study myocardial infarction. Biomarker of retinal degeneration. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5); INTERACTS WITH allethrin; atrazine; bisphenol A.

Tbx5

Homo sapiens

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Sall4

Rattus norvegicus

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including chordate embryonic development; embryonic limb morphogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of heterochromatin. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Duane retraction syndrome; Duane-radial ray syndrome; Holt-Oram syndrome; IVIC syndrome; and ventricular septal defect. Orthologous to human SALL4 (spalt like transcription factor 4); INTERACTS WITH aflatoxin B1; azoxystrobin; bisphenol A.