cla

Mus musculus

PHENOTYPE: Animals homozygous for this mutation exhibit clasping of the forefeet and hindfeet when held up by the tail. Animals have reduced body size and exhibit a fine whole body tremor. The hindfeet are held close together resulting in a hobbling gait. [provided by MGI curators]

crup

Mus musculus

PHENOTYPE: Mice homozygous for the mutation exhibit abnormal movement of hindlimbs when held by the tail. [provided by MGI curators]

Gena119

Mus musculus

PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit abnormal trunk curling and limb grasping when held by tail and some have tail kink, squint jaw. [provided by MGI curators]

how

Drosophila melanogaster

held out wings (how) encodes an RNA-binding protein highly expressed in the mesoderm and tendon cells. It is spliced into two isoforms: how(L) and how(S). how(L) induces RNA destabilization, whereas How(S) stabilizes the RNA targets.

Aak1

Rattus norvegicus

Enables AP-2 adaptor complex binding activity and protein serine/threonine kinase activity. Involved in presynaptic endocytosis and regulation of clathrin-dependent endocytosis. Located in cell leading edge and terminal bouton. Part of clathrin complex. Is active in calyx of Held. Orthologous to human AAK1 (AP2 associated kinase 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

LGALS13

Homo sapiens

Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]

Kcna3

Rattus norvegicus

Enables delayed rectifier potassium channel activity and outward rectifier potassium channel activity. Involved in corpus callosum development; optic nerve development; and potassium ion transmembrane transport. Located in membrane raft and plasma membrane. Is active in calyx of Held; glutamatergic synapse; and synaptic membrane. Orthologous to human KCNA3 (potassium voltage-gated channel subfamily A member 3); INTERACTS WITH acetamide; ammonium chloride; bisphenol A.

cdc14

Saccharomyces cerevisiae

Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response, autophagy during meiosis; downregulates microautophagy induction after TORC1 inactivation; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of cdc14-1 mutant

Kcnq5

Rattus norvegicus

Enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential and voltage-gated potassium channel activity. Involved in potassium ion transport. Is active in calyx of Held and presynaptic membrane. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5); INTERACTS WITH 1-naphthyl isothiocyanate; 6-propyl-2-thiouracil; ammonium chloride.

Tprg1l

Rattus norvegicus

Predicted to enable calmodulin binding activity and identical protein binding activity. Involved in presynaptic modulation of chemical synaptic transmission; regulation of glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in synaptic vesicle. Is active in calyx of Held and glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human TPRG1L (tumor protein p63 regulated 1 like); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol; 6-propyl-2-thiouracil.