vha-19

Caenorhabditis elegans

Predicted to enable ATPase activator activity. Involved in intracellular water homeostasis; positive regulation of oocyte development; and positive regulation of protein targeting to membrane. Located in membrane raft. Expressed in excretory canal; hypodermis; intestine; pharynx; and vulva. Human ortholog(s) of this gene implicated in immunodeficiency 47. Is an ortholog of human ATP6AP1 (ATPase H+ transporting accessory protein 1) and ATP6AP1L (ATPase H+ transporting accessory protein 1 like (pseudogene)).

vha-3

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Expressed in excretory cell; hypodermis; and intestinal cell. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Is an ortholog of human ATP6V0C (ATPase H+ transporting V0 subunit c).

vha-1

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including lysosomal lumen acidification; ovulation; and regulation of syncytium formation by plasma membrane fusion. Located in membrane raft. Expressed in excretory cell and rectum. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Is an ortholog of human ATP6V0C (ATPase H+ transporting V0 subunit c).

vha-2

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in programmed cell death and proton transmembrane transport. Predicted to be located in membrane. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Expressed in excretory cell and rectum. Human ortholog(s) of this gene implicated in early-onset epilepsy 3 and thyroid gland carcinoma. Is an ortholog of human ATP6V0C (ATPase H+ transporting V0 subunit c).

vha-4

Caenorhabditis elegans

Predicted to enable proton transmembrane transporter activity. Involved in embryo development. Predicted to be located in membrane. Predicted to be part of proton-transporting two-sector ATPase complex, proton-transporting domain. Expressed in excretory cell and rectum. Is an ortholog of human ATP6V0B (ATPase H+ transporting V0 subunit b).

vha-13

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in lysosomal lumen acidification. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Expressed in head. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IID and developmental and epileptic encephalopathy 93. Is an ortholog of human ATP6V1A (ATPase H+ transporting V1 subunit A).

vha-15

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Is an ortholog of human ATP6V1H (ATPase H+ transporting V1 subunit H).

vha-11

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in embryo development and ovulation. Predicted to be located in cytoplasm and membrane. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Expressed in excretory cell; hypodermis; and intestinal cell. Human ortholog(s) of this gene implicated in oral squamous cell carcinoma and stomach carcinoma. Is an ortholog of human ATP6V1C1 (ATPase H+ transporting V1 subunit C1).

vha-12

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including positive regulation of apoptotic process involved in development; positive regulation of neurotransmitter secretion; and regulation of intracellular pH. Predicted to be part of proton-transporting V-type ATPase, V1 domain. Expressed in excretory pore; hypodermal cell; muscle cell; neurons; and somatic cell. Human ortholog(s) of this gene implicated in autosomal dominant congenital deafness with onychodystrophy and renal tubular acidosis. Is an ortholog of human ATP6V1B2 (ATPase H+ transporting V1 subunit B2).

vha-8

Caenorhabditis elegans

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in proton transmembrane transport. Located in apical plasma membrane and cytoplasm. Expressed in head; hypodermis; and intestine. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIC. Is an ortholog of human ATP6V1E2 (ATPase H+ transporting V1 subunit E2).