akt-2

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

akt-1

Caenorhabditis elegans

Enables calmodulin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; regulation of synaptic assembly at neuromuscular junction; and signal transduction. Located in axon; cytoplasmic side of plasma membrane; and somatodendritic compartment. Expressed in several structures, including excretory canal; neurons; pharynx; rectal gland cell; and ventral nerve cord. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

eif-1.A

Caenorhabditis elegans

Predicted to enable translation initiation factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytoplasm. Expressed in head and tail. Is an ortholog of human EIF1AX (eukaryotic translation initiation factor 1A X-linked) and EIF1AY (eukaryotic translation initiation factor 1A Y-linked).

her-1

Caenorhabditis elegans

Enables signaling receptor binding activity. Involved in male sex determination. Located in extracellular region.

eas-1

Caenorhabditis elegans

Involved in Golgi vesicle transport. Located in cis-Golgi network. Expressed widely. Is an ortholog of human GOLT1A (golgi transport 1A) and GOLT1B (golgi transport 1B).

arp-1

Caenorhabditis elegans

Part of dynactin complex. Human ortholog(s) of this gene implicated in Down syndrome and colon cancer. Is an ortholog of human ACTR1A (actin related protein 1A).

zchc-1A

Caenorhabditis elegans

Predicted to enable metal ion binding activity. Is an ortholog of human ZC2HC1A (zinc finger C2HC-type containing 1A) and ZC2HC1B (zinc finger C2HC-type containing 1B).

eef-1A.1

Caenorhabditis elegans

Enables GTPase activity. Predicted to be involved in translational elongation. Predicted to be located in cytoplasm. Expressed in hypodermis; intestine; muscle cell; and neurons. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal dominant intellectual developmental disorder 38; developmental and epileptic encephalopathy 33; and ovarian cancer. Is an ortholog of human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1); EEF1A1P5 (eukaryotic translation elongation factor 1 alpha 1 pseudogene 5); and EEF1A2 (eukaryotic translation elongation factor 1 alpha 2).

eak-3

Caenorhabditis elegans

Expressed in XXXL and XXXR.

icln-1

Caenorhabditis elegans

Predicted to be involved in mRNA cis splicing, via spliceosome and spliceosomal snRNP assembly. Predicted to be located in cytosol. Predicted to be part of pICln-Sm protein complex and spliceosomal complex. Is an ortholog of human CLNS1A (chloride nucleotide-sensitive channel 1A).