Enriched in ABplpapppa and NSM based on tiling array and single-cell RNA-seq studies. Is affected by age-1; spn-4; and ogt-1 based on microarray and RNA-seq studies.
Enriched in neurons based on tiling array; single-cell RNA-seq; and RNA-seq studies. Is affected by several genes including rsr-2; clk-1; and age-1 based on microarray; tiling array; and RNA-seq studies.
Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including dauer entry; determination of adult lifespan; and regulation of synaptic assembly at neuromuscular junction. Located in cytoplasm and non-motile cilium. Part of phosphatidylinositol 3-kinase complex. Expressed in amphid neurons; anchor cell; hypodermis; and pharyngeal-intestinal valve. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); gastrointestinal system cancer (multiple); and reproductive organ cancer (multiple). Is an ortholog of human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta); and PIK3CG (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma).
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).
An extracellular matrix structural constituent. Involved in basement membrane disassembly. Located in basement membrane. Expressed in body wall musculature; germ cell; germ line; gonad; and pharynx. Human ortholog(s) of this gene implicated in age related macular degeneration 1. Is an ortholog of human HMCN1 (hemicentin 1).
Predicted to enable transmembrane receptor protein tyrosine kinase activity. Predicted to be located in plasma membrane. Predicted to be part of receptor complex. Expressed in hypodermis; male gonad; neurons; and pharynx. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); and prostate cancer. Is an ortholog of human FLT3 (fms related receptor tyrosine kinase 3).