tom-1

Caenorhabditis elegans

Predicted to enable GTPase activator activity; myosin II binding activity; and syntaxin binding activity. Involved in several processes, including regulation of presynaptic dense core granule exocytosis; regulation of synaptic vesicle docking; and synaptic vesicle priming. Located in GABA-ergic synapse; cholinergic synapse; and neuromuscular junction. Is extrinsic component of neuronal dense core vesicle membrane. Part of SNARE complex. Expressed in head neurons; tail neurons; and ventral cord neurons. Is an ortholog of human STXBP5 (syntaxin binding protein 5).

Tom6

Saccharomyces cerevisiae

Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

Tom7

Saccharomyces cerevisiae

Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex

Cbr-tom-1

Caenorhabditis briggsae

Is an ortholog of C. elegans tom-1. In C. elegans, tom-1 is involved in several processes, including regulation of presynaptic dense core granule exocytosis; regulation of synaptic vesicle docking; and synaptic vesicle priming.

Ppa-tom-1

Pristionchus pacificus

Is an ortholog of C. elegans tom-1. In C. elegans, tom-1 is involved in several processes, including regulation of presynaptic dense core granule exocytosis; regulation of synaptic vesicle docking; and synaptic vesicle priming.

TOM22

Saccharomyces cerevisiae

Component of the TOM (Translocase of Outer Membrane) complex; responsible for initial import of mitochondrially directed proteins; mediates interaction between TOM and TIM complexes and acts as receptor for precursor proteins; implicated in mitochondrial accumulation of amyloid beta peptides via direct interaction with amyloid beta peptide residues 25-42 followed by transfer to Tom40p and transport through the TOM channel

Cjp-tom-1.2

Caenorhabditis japonica

Is an ortholog of C. elegans tom-1. In C. elegans, tom-1 is involved in several processes, including regulation of presynaptic dense core granule exocytosis; regulation of synaptic vesicle docking; and synaptic vesicle priming.

Tom70

Drosophila melanogaster

Translocase of outer membrane 70 (Tom70) encodes a mitochondrial protein that may act as a receptor of the TOM complex based on orthology. TOM complex is involved in protein import into mitochondria. The product of Tom70 modulates cell death induced by the expression of the mouse Bax protein.

Tom

Drosophila melanogaster

Twin of m4 (Tom) is a member of the Bearded gene family that encodes a regulator of the Notch signaling pathway.

Cre-tom-1

Caenorhabditis remanei

Is predicted to encode a protein with the following domains: Lethal giant larvae (Lgl)-like, C-terminal domain and Lethal giant larvae(Lgl) like, C-terminal. Is an ortholog of C. elegans tom-1. In C. elegans, tom-1 is involved in several processes, including regulation of presynaptic dense core granule exocytosis; regulation of synaptic vesicle docking; and synaptic vesicle priming.