Cd177

Homo sapiens

This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]

Elane

Rattus norvegicus

Predicted to enable several functions, including heparin binding activity; serine-type endopeptidase activity; and transcription corepressor activity. Involved in leukocyte migration involved in inflammatory response and positive regulation of leukocyte tethering or rolling. Predicted to be located in cell surface and secretory granule. Predicted to be part of transcription repressor complex. Predicted to be active in extracellular space. Used to study several diseases, including cerebrovascular disease (multiple); lung disease (multiple); mucositis; pleurisy; and polycythemia vera. Biomarker of suppurative periapical periodontitis. Human ortholog(s) of this gene implicated in cyclic hematopoiesis; periodontitis; severe congenital neutropenia; and severe congenital neutropenia 1. Orthologous to human ELANE (elastase, neutrophil expressed); PARTICIPATES IN systemic lupus erythematosus pathway; INTERACTS WITH amphetamine; andrographolide; anilines.