Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in establishment or maintenance of cell polarity and vulval development. Predicted to be located in plasma membrane. Expressed in several structures, including P3.pa; P3.pp; P4.pa; P4.pp; and P8.pa. Is an ortholog of human RHOU (ras homolog family member U).
Predicted to enable GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ip. Is an ortholog of human ALG11 (ALG11 alpha-1,2-mannosyltransferase).
Predicted to enable dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity. Predicted to be involved in protein glycosylation. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Id. Is an ortholog of human ALG3 (ALG3 alpha-1,3- mannosyltransferase).
Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of Ras protein signal transduction; and vulval cell fate specification. Located in nucleus. Expressed in several structures, including P3.pa; P3.pp; P4.pa; P5.ppp; and P7.paa. Is an ortholog of human SBNO1 (strawberry notch homolog 1).
This gene encodes a GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase which is localized to the cytosolic side of the endoplasmic reticulum (ER) and catalyzes the transfer of the fourth and fifth mannose residue from GDP-mannose (GDP-Man) to Man3GlcNAc2-PP-dolichol and Man4GlcNAc2-PP-dolichol resulting in the production of Man5GlcNAc2-PP-dolichol. Mutations in this gene are associated with congenital disorder of glycosylation type Ip (CDGIP). This gene overlaps but is distinct from the UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) gene. A pseudogene of the GDP-Man:Man3GlcNAc2-PP-dolichol-alpha1,2-mannosyltransferase has been identified on chromosome 19. [provided by RefSeq, Aug 2010]