Predicted to enable tRNA dimethylallyltransferase activity. Involved in determination of adult lifespan and regulation of growth. Located in mitochondrion and nucleus. Expressed widely. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Is an ortholog of human TRIT1 (tRNA isopentenyltransferase 1).
Hairless (H) encodes the major antagonist of Notch signaling activity during imaginal development. It silences target genes of the product of N by assembling a transcriptional repressor complex, which includes the transcription factor encoded by Su(H) and general co-repressors like those encoded by gro and CtBP.
groucho (gro) encodes a global developmental co-repressor in conjunction with manifold DNA-binding repressor partner proteins, which tether it to target promoters. It functions downstream of key signaling pathways such as Wg/Wnt and Dpp/TGF-beta. Notably, phosphorylation of the product of gro in response to MAPK activation weakens its repressor capacity.
Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA processing. Is an ortholog of C. elegans gro-1. In C. elegans, gro-1 is involved in determination of adult lifespan and regulation of growth.
Predicted to enable beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Is an ortholog of human MANBA (mannosidase beta).
Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA processing. Is an ortholog of C. elegans gro-1. In C. elegans, gro-1 is involved in determination of adult lifespan and regulation of growth.
Predicted to enable glycosyltransferase activity. Predicted to be involved in macromolecule glycosylation. Predicted to be located in Golgi cisterna membrane.
Predicted to enable tRNA dimethylallyltransferase activity. Predicted to be involved in tRNA processing. Is an ortholog of C. elegans gro-1. In C. elegans, gro-1 is involved in determination of adult lifespan and regulation of growth.
Enables tyramine-beta hydroxylase activity. Involved in octopamine biosynthetic process. Located in synapse. Expressed in RICL; RICR; and gonad. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; and dopamine beta-hydroxylase deficiency. Is an ortholog of human DBH (dopamine beta-hydroxylase).