PGC1

Saccharomyces cerevisiae

Phosphatidylglycerol phospholipase C; regulates phosphatidylglycerol (PG) accumulation via a phospholipase C-type degradation mechanism; PG levels affect mitochondrial function; contains glycerophosphodiester phosphodiesterase motifs

Stpg2

Rattus norvegicus

Orthologous to human STPG2 (sperm tail PG-rich repeat containing 2); INTERACTS WITH 17beta-estradiol; acrylamide; atrazine.

Stpg3

Rattus norvegicus

Predicted to be active in cytoskeleton. Orthologous to human STPG3 (sperm-tail PG-rich repeat containing 3); INTERACTS WITH bisphenol A; Cuprizon; gentamycin.

itr-1

Caenorhabditis elegans

Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; mating behavior; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; autosomal dominant cerebellar ataxia (multiple); and diabetes mellitus (multiple). Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).

Stpg1

Rattus norvegicus

Predicted to be involved in positive regulation of apoptotic process and positive regulation of mitochondrial membrane permeability involved in apoptotic process. Predicted to be located in mitochondrion and nucleus. Orthologous to human STPG1 (sperm tail PG-rich repeat containing 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.

DDL1

Saccharomyces cerevisiae

DDHD domain-containing phospholipase A1; mitochondrial matrix enzyme with sn-1-specific activity, hydrolyzing cardiolipin, PE, PC, PG and PA; implicated in remodeling of mitochondrial phospholipids; antagonistically regulated by Aft1p and Aft2p; in humans, mutations in DDHD1 and DDHD2 genes cause specific types of hereditary spastic paraplegia, while DDL1-defective yeast share similar phenotypes such as mitochondrial dysfunction and defects in lipid metabolism

Stpg4

Rattus norvegicus

Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in epigenetic programing of male pronucleus. Predicted to act upstream of or within 5-methylcytosine catabolic process. Predicted to be located in cytoplasm; female germ cell nucleus; and male germ cell nucleus. Predicted to be active in female pronucleus; germinal vesicle; and male pronucleus. Orthologous to human STPG4 (sperm-tail PG-rich repeat containing 4); INTERACTS WITH 6-propyl-2-thiouracil; acetamide; bisphenol A.

Itpr1

Rattus norvegicus

Enables several functions, including ATP binding activity; inositol 1,4,5-trisphosphate-gated calcium channel activity; and transmembrane transporter binding activity. Involved in several processes, including calcium ion transmembrane transport; cellular response to cAMP; and regulation of apoptotic process. Located in several cellular components, including endoplasmic reticulum; neuronal cell body; and synaptic membrane. Part of protein-containing complex. Is active in several cellular components, including GABA-ergic synapse; postsynapse; and smooth endoplasmic reticulum membrane. Used to study asthma. Biomarker of Huntington's disease; cardiac arrest; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Akr1c3

Homo sapiens

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]