Magi

Drosophila melanogaster

Magi (Magi) encodes a molecular scaffolding protein that is involved in adherens junction (AJ) organization. Magi is ubiquitously expressed and its product localizes at AJ with the Par polarity complex.

ASPP

Drosophila melanogaster

Ankyrin-repeat, SH3-domain, and Proline-rich-region containing Protein (ASPP) encodes a scaffold protein localised at the adherens junctions (AJ) of epithelial cells. It promotes AJ stability by repressing Src activity via the kinase encoded by Csk.

itr-1

Caenorhabditis elegans

Enables myosin binding activity. Involved in several processes, including determination of adult lifespan; mating behavior; and system process. Located in endoplasmic reticulum and membrane. Expressed in several structures, including egg-laying apparatus; ganglia; gonad; non-striated muscle; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Gillespie syndrome; autosomal dominant cerebellar ataxia (multiple); and diabetes mellitus (multiple). Is an ortholog of human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); and ITPR3 (inositol 1,4,5-trisphosphate receptor type 3).

Or2aj4b

Rattus norvegicus

Predicted to enable olfactory receptor activity. Predicted to be involved in detection of chemical stimulus involved in sensory perception of smell. Predicted to be active in plasma membrane. Orthologous to human OR2AJ1 (olfactory receptor family 2 subfamily AJ member 1); INTERACTS WITH copper atom; copper(0).

Itpr1

Rattus norvegicus

Enables several functions, including ATP binding activity; inositol 1,4,5-trisphosphate-gated calcium channel activity; and transmembrane transporter binding activity. Involved in several processes, including calcium ion transmembrane transport; cellular response to cAMP; and regulation of apoptotic process. Located in several cellular components, including endoplasmic reticulum; neuronal cell body; and synaptic membrane. Part of protein-containing complex. Is active in several cellular components, including GABA-ergic synapse; postsynapse; and smooth endoplasmic reticulum membrane. Used to study asthma. Biomarker of Huntington's disease; cardiac arrest; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Gillespie syndrome; spinocerebellar ataxia type 15; and spinocerebellar ataxia type 29. Orthologous to human ITPR1 (inositol 1,4,5-trisphosphate receptor type 1); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.