- tdo-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable heme binding activity and tryptophan 2,3-dioxygenase activity. Predicted to be involved in tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Is an ortholog of human TDO2 (tryptophan 2,3-dioxygenase).
- HHT2 [Search on AGR]
Saccharomyces cerevisiae Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage
- Slitrk1 [Search on AGR]
Rattus norvegicus Involved in regulation of synapse organization. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density membrane. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and trichotillomania. Orthologous to human SLITRK1 (SLIT and NTRK like family member 1); INTERACTS WITH 17alpha-ethynylestradiol; alpha-Zearalanol; bisphenol A.
- HHT1 [Search on AGR]
Saccharomyces cerevisiae Histone H3; core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation; H3K14 acetylation plays an important role in the unfolding of strongly positioned nucleosomes during repair of UV damage
- Tdo2 [Search on AGR]
Rattus norvegicus Enables several functions, including heme binding activity; oxygen binding activity; and tryptophan 2,3-dioxygenase activity. Involved in response to nitroglycerin and tryptophan catabolic process to acetyl-CoA. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome and familial hypertryptophanemia. Orthologous to human TDO2 (tryptophan 2,3-dioxygenase); PARTICIPATES IN tryptophan metabolic pathway; kynurenine metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-di-tert-butyl-4-methylphenol.
- Hdc [Search on AGR]
Rattus norvegicus Enables several functions, including histidine decarboxylase activity; identical protein binding activity; and pyridoxal phosphate binding activity. Involved in L-histidine metabolic process and histamine metabolic process. Located in dendrite and neuronal cell body. Biomarker of rhinitis. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase); PARTICIPATES IN histidine metabolic pathway; histidinemia pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,5'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
- Hcn4 [Search on AGR]
Rattus norvegicus Predicted to enable identical protein binding activity and monoatomic cation channel activity. Involved in cellular response to aldosterone. Located in basolateral plasma membrane; neuronal cell body; and terminal bouton. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; aconitine.
- Baiap2 [Search on AGR]
Rattus norvegicus Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; cellular response to epidermal growth factor stimulus; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,6-dinitrotoluene.
- Drd4 [Search on AGR]
Rattus norvegicus Enables dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and heterocyclic compound binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and regulation of signal transduction. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Biomarker of attention deficit hyperactivity disorder and obesity. Human ortholog(s) of this gene implicated in several diseases, including Gilles de la Tourette syndrome; antisocial personality disorder; attention deficit hyperactivity disorder; conduct disorder; and substance abuse (multiple). Orthologous to human DRD4 (dopamine receptor D4); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; 1,2-dimethylhydrazine; 3,7-dihydropurine-6-thione.
- Drd2 [Search on AGR]
Rattus norvegicus Enables several functions, including dopamine binding activity; dopamine neurotransmitter receptor activity, coupled via Gi/Go; and ionotropic glutamate receptor binding activity. Involved in several processes, including modulation of chemical synaptic transmission; nervous system development; and regulation of signal transduction. Located in several cellular components, including cytoplasmic vesicle; lateral plasma membrane; and perikaryon. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Used to study Parkinsonism; cocaine dependence; fetal alcohol spectrum disorder; and ovarian hyperstimulation syndrome. Biomarker of several diseases, including Gilles de la Tourette syndrome; drug psychosis; hyperprolactinemia; opiate dependence (multiple); and toxic encephalopathy. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; drug dependence (multiple); end stage renal disease; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human DRD2 (dopamine receptor D2); PARTICIPATES IN dopamine signaling pathway; excitatory synaptic transmission pathway; dopamine signaling pathway via D2 family of receptors; INTERACTS WITH (+)-butaclamol; (+)-pilocarpine; (R)-noradrenaline.