anat-1

Caenorhabditis elegans

Predicted to enable N-acetyltransferase activity.

tal-AA

Drosophila melanogaster

tarsal-less AA (tal-AA) encodes one of four open reading frames within the tal polycistronic transcription unit. The encoded peptide controls the post-transcriptional activation of the product of ovo, which in turn regulates Notch signalling and F-actin organization.

IL12A-AS1

Homo sapiens

ASSOCIATED WITH AA amyloidosis; Abdominal pain; Abnormal blistering of the skin; INTERACTS WITH benzo[e]pyrene; methapyrilene

TEF4

Saccharomyces cerevisiae

Gamma subunit of translational elongation factor eEF1B; stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex

hpo-35

Caenorhabditis elegans

Enriched in AVK and germ line based on RNA-seq studies. Is affected by several genes including nuo-6; isp-1; and mrps-5 based on RNA-seq; proteomic; and microarray studies. Is affected by eight chemicals including Alovudine; stavudine; and Zidovudine based on RNA-seq and microarray studies.

Pla2g1b

Homo sapiens

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

Sst

Homo sapiens

The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]

Jevr

Mus musculus

PHENOTYPE: Strains respond differently to Japanese encephalitis virus (JEV) infection. For intraperitoneal inoculation, C3H/He mice show high infection and mortality rates; C57BL/6, RR, NC and KK mice show high infection and low mortality. AA, BALB/c and ddY mice show low infection and no mortality. [provided by MGI curators]

Thop1

Homo sapiens

The protein encoded by this gene is a kininase that uses zinc as a cofactor. The encoded oligopeptidase cleaves cytosolic peptides, making them unavailable for display on antigen-presenting cells. This protein also cleaves neuropeptides under 20 aa in length and can degrade beta-amyloid precursor protein to amyloidogenic peptides. [provided by RefSeq, Nov 2015]

Ggnbp1

Homo sapiens

This gene is the ortholog of the mouse gametogenetin-binding protein 1 gene. In human, the open reading frame is disrupted by a nonsense mutation after 8-aa; consequently, this gene is currently considered to be a unitary pseudogene in human even though it is functional in other mammals. [provided by RefSeq, Aug 2009]