F27C1.11

Caenorhabditis elegans

Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; autosomal recessive nonsyndromic deafness 77; and orofacial cleft. Is an ortholog of human LOXHD1 (lipoxygenase homology PLAT domains 1).

abts-3

Caenorhabditis elegans

Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion homeostasis and transmembrane transport. Predicted to be located in basolateral plasma membrane. Expressed in hypodermis and neurons. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Is an ortholog of human SLC4A11 (solute carrier family 4 member 11).

T13G4.4

Caenorhabditis elegans

Predicted to enable S-adenosylmethionine-homocysteine S-methyltransferase activity. Predicted to be involved in S-methylmethionine cycle and methionine biosynthetic process.

gst-34

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

W10C8.4

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

gst-35

Caenorhabditis elegans

Predicted to enable glutathione transferase activity. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Is an ortholog of several human genes including GSTA1 (glutathione S-transferase alpha 1); GSTA2 (glutathione S-transferase alpha 2); and GSTA3 (glutathione S-transferase alpha 3).

ccpp-1

Caenorhabditis elegans

Predicted to enable metallocarboxypeptidase activity and zinc ion binding activity. Involved in egg-laying behavior. Predicted to be located in cilium; dendrite; and perikaryon. Expressed in ciliated neurons and gubernacular muscle. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Is an ortholog of human AGBL1 (AGBL carboxypeptidase 1).

msra-1

Caenorhabditis elegans

Enables L-methionine:thioredoxin-disulfide S-oxidoreductase activity and peptide-methionine (S)-S-oxide reductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in cytoplasm. Expressed in hypodermis and neurons. Is an ortholog of human MSRA (methionine sulfoxide reductase A).

slc-25A26

Caenorhabditis elegans

Enables S-adenosyl-L-methionine transmembrane transporter activity. Involved in mitochondrial S-adenosyl-L-methionine transmembrane transport. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 28. Is an ortholog of human SLC25A26 (solute carrier family 25 member 26).

Agbl1

Rattus norvegicus

Predicted to enable metallocarboxypeptidase activity and tubulin binding activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy. Orthologous to human AGBL1 (AGBL carboxypeptidase 1); INTERACTS WITH alpha-Zearalanol; atrazine; bisphenol A.