- dpyd-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable NADP binding activity; dihydropyrimidine dehydrogenase (NADP+) activity; and uracil binding activity. Predicted to be involved in thymidine catabolic process; thymine catabolic process; and uracil catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; dihydropyrimidine dehydrogenase deficiency; and gallbladder cancer. Is an ortholog of human DPYD (dihydropyrimidine dehydrogenase).
- M7321Wlst [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit excessive platelet production following 5-FU treatment. [provided by MGI curators]
- M7324Wlst [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit delayed recovery from 5-FU treatment. [provided by MGI curators]
- M7325Wlst [Search on AGR]
Mus musculus PHENOTYPE: Mice heterozygous for an ENU-induced allele exhibit excessive production of platelets following 5-FU treatment. [provided by MGI curators]
- HAM1 [Search on AGR]
Saccharomyces cerevisiae Nucleoside triphosphate pyrophosphohydrolase; active against various substrates including ITP, dITP and XTP; mediates exclusion of non canonical purines, pyrimidines from dNTP pools; functions with YJL055W to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA without affecting uptake or incorporation of uracil into RNA; protein abundance increases in response to DNA replication stress; yeast HAM1 can complement knockdown of human homolog ITPA
- upp-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables thymidine phosphorylase activity and uridine phosphorylase activity. Involved in thymidine metabolic process; uracil catabolic process; and uridine catabolic process. Predicted to be located in cytosol. Expressed in gonad; hypodermis; pharynx; and spermatheca. Is an ortholog of human UPP1 (uridine phosphorylase 1) and UPP2 (uridine phosphorylase 2).
- LOG1 [Search on AGR]
Saccharomyces cerevisiae Putative protein of unknown function; functions together with HAM1 to mediate resistance to 5-FU; specifically reduces the incorporation of 5-FU into RNA, without affecting uptake or incorporation of uracil into RNA; proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA
- Sart3 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a conditional allele activated in hematopoietic cells exhibit protection against the effects of 5-FU treatment. [provided by MGI curators]
- Fbxo21 [Search on AGR]
Mus musculus PHENOTYPE: Mice homozygous for a conditional allele activated in hematopoietic cells exhibit increased susceptibility to 5-FU-induced bone marrow failure and lethality. [provided by MGI curators]
- Su(fu) [Search on AGR]
Drosophila melanogaster Suppressor of fused (Su(fu)) encodes a negative regulator of the Hedgehog signaling pathway. It forms a complex with the transcription factor encoded by ci to inhibit its activity.