furry (fry) encodes a large conserved protein that functions with the product of trc. Its mutations lead to mulitpled hairs, split and multipled arista laterals and to defects in dendritic tiling.
PHENOTYPE: Mice homozygous for an ENU induced allele that segregates with Kl<sup>m1Btlr</sup> exhibit short tibia, femur, and pelvis. [provided by MGI curators]
ENCODES a protein that exhibits enzyme inhibitor activity (inferred); INVOLVED IN cell morphogenesis (inferred); negative regulation of tubulin deacetylation (inferred); ASSOCIATED WITH hereditary breast ovarian cancer syndrome; FOUND IN centrosome (inferred); cytoplasm (inferred); cytoskeleton (inferred); INTERACTS WITH (-)-demecolcine; (-)-epigallocatechin 3-gallate; 17beta-estradiol
Predicted to enable enzyme inhibitor activity. Predicted to be involved in cell morphogenesis; negative regulation of tubulin deacetylation; and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. Orthologous to human FRY (FRY microtubule binding protein); INTERACTS WITH 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil; acetamide.
Involved in neuron projection development. Predicted to be located in cell cortex and site of polarized growth. Expressed in head neurons; tail neurons; and ventral nerve cord. Is an ortholog of human FRY (FRY microtubule binding protein) and FRYL (FRY like transcription coactivator).
Predicted to be involved in cell morphogenesis and neuron projection development. Predicted to be active in cell cortex and site of polarized growth. Orthologous to human FRYL (FRY like transcription coactivator); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.