ace-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholinesterase activity and identical protein binding activity. Involved in acetylcholine catabolic process and regulation of locomotion. Located in extracellular space. Expressed in CEP; M cell; OLL; body wall musculature; and non-striated muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase).
Ache [Search on AGR]
Rattus norvegicus Enables acetylcholine binding activity; acetylcholinesterase activity; and choline binding activity. Involved in several processes, including acetylcholine catabolic process; nervous system development; and positive regulation of neurogenesis. Located in several cellular components, including endoplasmic reticulum lumen; membrane raft; and synaptic membrane. Is active in neuromuscular junction and synaptic cleft. Biomarker of acute stress disorder and leptospirosis. Human ortholog(s) of this gene implicated in Alzheimer's disease; epilepsy; and myasthenia gravis. Orthologous to human ACHE (acetylcholinesterase (Yt blood group)); PARTICIPATES IN acetylcholine metabolic pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptor; acetylcholine signaling pathway via nicotinic acetylcholine receptor; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (+)-taxifolin.
ace-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables acetylcholinesterase activity and protein homodimerization activity. Involved in several processes, including acetylcholine catabolic process; hatching; and regulation of backward locomotion. Predicted to be located in extracellular space and plasma membrane. Expressed in body wall musculature; neurons; pharyngeal muscle cell; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; artery disease (multiple); and autoimmune disease (multiple). Is an ortholog of human ACHE (acetylcholinesterase (Yt blood group)) and BCHE (butyrylcholinesterase).
Ache [Search on AGR]
Homo sapiens Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission. It is also found on the red blood cell membranes, where it constitutes the Yt blood group antigen. Acetylcholinesterase exists in multiple molecular forms which possess similar catalytic properties, but differ in their oligomeric assembly and mode of cell attachment to the cell surface. It is encoded by the single ACHE gene, and the structural diversity in the gene products arises from alternative mRNA splicing, and post-translational associations of catalytic and structural subunits. The major form of acetylcholinesterase found in brain, muscle and other tissues is the hydrophilic species, which forms disulfide-linked oligomers with collagenous, or lipid-containing structural subunits. The other, alternatively spliced form, expressed primarily in the erythroid tissues, differs at the C-terminal end, and contains a cleavable hydrophobic peptide with a GPI-anchor site. It associates with the membranes through the phosphoinositide (PI) moieties added post-translationally. AChE activity may constitute a sensitive biomarker of RBC ageing in vivo, and thus, may be of aid in understanding the effects of transfusion[provided by RefSeq, Sep 2019]