- Swim [Search on AGR]
Drosophila melanogaster Secreted Wg-interacting molecule (Swim) encodes a secreted protein that binds to the product of wg and may function in its spreading.
- sona [Search on AGR]
Drosophila melanogaster sol narae (sona) encodes a member of the ADAMTS family of proteases secreted to the extracellular matrix. It is involved in Wg signaling by promoting the secretion of the product of wg, and is essential for development and growth.
- Cow [Search on AGR]
Drosophila melanogaster Carrier of Wingless (Cow) encodes a secreted heparan sulfate proteoglycan that binds the product of wg and increases its extracellular mobility. The binding with the ligand encoded by wg is dependent on heparan sulfate modification of the product of Cow.
- por [Search on AGR]
Drosophila melanogaster porcupine (por) encodes an O-acyltransferase that is an essential component of the Wingless/Wnt pathway by mediating lipidation of the product of wg. It targets the product of wg to secretory vesicles that deliver the ligand to specialized microdomains at the cell surface where it can be packaged for secretion.
- dlp [Search on AGR]
Drosophila melanogaster dally-like (dlp) encodes a glypican that regulates the signaling strength and range of the morphogens encoded by hh and wg.
- wg [Search on AGR]
Drosophila melanogaster wingless (wg) is a segment polarity gene that encodes a ligand of the Wnt/Wg signaling pathway. Its post-translational modification (addition of palmitoleate by the product of por) is essential for signaling activity. It contributes to segment polarity, tissue growth and patterning, neuromuscular junction morphogenesis, gut homeostasis and long term memory formation.
- Coop [Search on AGR]
Drosophila melanogaster Corepressor of Pangolin (Coop) encodes a protein that represses gene expression mediated by Wg signaling. It binds to the product of pan preventing the interaction of the products of pan with arm. By antagonizing Wg signaling, it contributes to patterning and cell fate decisions during development.
- lbe [Search on AGR]
Drosophila melanogaster ladybird early (lbe) encodes a transcription factor involved in muscle and heart development. It also plays a role in regulating the embryonic expression of wg.
- lbl [Search on AGR]
Drosophila melanogaster ladybird late (lbl) encodes a transcription factor involved in muscle and heart development. It also plays a role in regulating the embryonic expression of wg.
- Sulf1 [Search on AGR]
Drosophila melanogaster Sulfated (Sulf1) encodes a heparan sulfate modifying enzyme, which extracellularly removes specific 6-O-sulfate groups from heparan sulfate in a post-synthetic manner. It regulates Wg signaling by reducing extracellular wg protein levels. It also regulates Hh signaling by acting as a positive regulator in cells producing the product of hh and a negative regulator in cells receiving the product of hh.