- SC [Search on AGR]
Drosophila melanogaster scute (sc) is a proneural gene of the achaete-scute complex. It encodes a transcription factor involved in nervous system development, Notch signalling and sex determination.
- GMC2 [Search on AGR]
Saccharomyces cerevisiae Protein involved in meiotic crossing over; component of the Synaptonemal Complex (SC) along with Ecm11p; required for the efficient loading of the SC transverse filament protein, Zip1p; promotes SUMOylation of Ecm11p; mutants are delayed in meiotic nuclear division and are defective in synaptonemal complex assembly; transcription is regulated by Ume6p and induced in response to alpha factor; also detected in peroxisomes
- ECM11 [Search on AGR]
Saccharomyces cerevisiae Meiosis-specific protein; component of the Synaptonemal Complex (SC) along with Gmc2p; required for efficient crossover formation and for the efficient loading of the SC transverse filament protein, Zip1p; is SUMOlytaed in a Gmc2p manner, and SUMOylation is required for its function in meiosis; GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure
- SLC2A14 [Search on AGR]
Homo sapiens ENCODES a protein that exhibits dehydroascorbic acid transmembrane transporter activity; glucose transmembrane transporter activity; INVOLVED IN dehydroascorbic acid transport; glucose transmembrane transport; ASSOCIATED WITH developmental and epileptic encephalopathy 21; Hyperphosphatemic Familial Tumoral Calcinosis 1; Klippel-Feil syndrome 3; FOUND IN aggresome; plasma membrane; INTERACTS WITH 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one; 3-isobutyl-1-methyl-7H-xanthine
- RED1 [Search on AGR]
Saccharomyces cerevisiae Protein component of the synaptonemal complex axial elements; involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; promotes interhomolog recombination by phosphorylating Hop1p; also interacts with Mec3p and Ddc1p
- CLEC4C [Search on AGR]
Homo sapiens ENCODES a protein that exhibits carbohydrate binding (inferred); metal ion binding (inferred); INVOLVED IN positive regulation of release of sequestered calcium ion into cytosol (ortholog); ASSOCIATED WITH developmental and epileptic encephalopathy 21; Hyperphosphatemic Familial Tumoral Calcinosis 1; Klippel-Feil syndrome 3; FOUND IN ficolin-1-rich granule membrane (inferred); membrane (inferred); plasma membrane (inferred); INTERACTS WITH 4,4'-sulfonyldiphenol; benzo[a]pyrene; formaldehyde
- zhp-3 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable SUMO transferase activity. Involved in embryo development; meiotic chromosome segregation; and synaptonemal complex disassembly. Located in synaptonemal complex. Is an ortholog of human RNF212B (ring finger protein 212B).
- Myo18b [Search on AGR]
Rattus norvegicus Predicted to enable actin filament binding activity. Predicted to be involved in actomyosin structure organization. Predicted to act upstream of or within cardiac muscle cell development; in utero embryonic development; and vasculogenesis. Predicted to be located in Z disc. Predicted to be part of filamentous actin; myosin II complex; and unconventional myosin complex. Predicted to be active in cytoplasm and myosin filament. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 4. Orthologous to human MYO18B (myosin XVIIIB); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; alpha-Zearalanol.