let-23

Caenorhabditis elegans

Enables epidermal growth factor receptor activity; lipid binding activity; and molecular function activator activity. Involved in several processes, including determination of adult lifespan; positive regulation of vulval development; and reproductive structure development. Located in cell-cell junction and plasma membrane. Expressed in several structures, including apoptotic cell; egg-laying apparatus; excretory duct cell; head; and vulval precursor cell. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypertension (multiple); and reproductive organ cancer (multiple). Is an ortholog of human EGFR (epidermal growth factor receptor) and ERBB4 (erb-b2 receptor tyrosine kinase 4).

Ereg

Homo sapiens

This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]

Erbb3

Rattus norvegicus

Enables neuregulin binding activity and neuregulin receptor activity. Involved in several processes, including cellular response to mechanical stimulus; mammary gland involution; and positive regulation of glucose import. Located in neuronal cell body and postsynaptic membrane. Biomarker of chronic obstructive pulmonary disease and median neuropathy. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; angiotensin II signaling pathway via AT2 receptor; calcium/calcium-mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Erbb2

Rattus norvegicus

Enables Hsp90 protein binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including ERBB2-ERBB4 signaling pathway; nervous system development; and positive regulation of intracellular signal transduction. Located in several cellular components, including basolateral plasma membrane; lateral loop; and postsynaptic membrane. Biomarker of congestive heart failure and median neuropathy. Human ortholog(s) of this gene implicated in several diseases, including lung cancer (multiple); mammary Paget's disease; reproductive organ cancer (multiple); stomach cancer; and urinary system cancer (multiple). Orthologous to human ERBB2 (erb-b2 receptor tyrosine kinase 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; Ras mediated signaling pathway; altered epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-acetamidofluorene; 3,3',5,5'-tetrabromobisphenol A.

Erbb4

Rattus norvegicus

Enables neuregulin receptor activity. Involved in several processes, including cellular response to L-glutamate; modulation of chemical synaptic transmission; and nervous system development. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Is active in plasma membrane. Used to study visual epilepsy. Biomarker of congestive heart failure; median neuropathy; radiculopathy; and schizophrenia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; calcium/calcium-mediated signaling pathway; endocytosis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 3-chloropropane-1,2-diol.