- anc-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable actin binding activity and kinesin binding activity. Involved in cytoskeleton organization; nucleus organization; and pronuclear migration. Located in nuclear envelope and perinuclear region of cytoplasm. Expressed in several structures, including body wall musculature; intestinal cell; and vulval muscle. Used to study Emery-Dreifuss muscular dystrophy. Human ortholog(s) of this gene implicated in arthrogryposis multiplex congenita-3; autosomal dominant Emery-Dreifuss muscular dystrophy 4; autosomal dominant Emery-Dreifuss muscular dystrophy 5; autosomal recessive spinocerebellar ataxia 8; and bipolar disorder. Is an ortholog of human SYNE1 (spectrin repeat containing nuclear envelope protein 1).
- lmn-1 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Enables histone binding activity; identical protein binding activity; and structural molecule activity. Involved in several processes, including determination of adult lifespan; nuclear pore localization; and regulation of cell cycle. Located in nuclear envelope and nuclear periphery. Expressed in several structures, including ventral cord blast cell. Used to study Emery-Dreifuss muscular dystrophy; congenital muscular dystrophy; and progeria. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; autosomal dominant Emery-Dreifuss muscular dystrophy 2; autosomal recessive Emery-Dreifuss muscular dystrophy 3; brain disease (multiple); congenital muscular dystrophy due to LMNA mutation; and intrinsic cardiomyopathy (multiple). Is an ortholog of human LMNA (lamin A/C).
- PGRP-LE [Search on AGR]
Drosophila melanogaster Peptidoglycan recognition protein LE (PGRP-LE) encodes an intracellular protein that interacts with DAP-type peptidoglycan to activate the immune deficiency pathway, notably in the midgut.
- SYNE1-AS1 [Search on AGR]
Homo sapiens ASSOCIATED WITH arthrogryposis multiplex congenita-3; autosomal dominant Emery-Dreifuss muscular dystrophy 4; autosomal recessive spinocerebellar ataxia 8
- Fam227a [Search on AGR]
Homo sapiens ASSOCIATED WITH adenylosuccinase lyase deficiency; Emery-Dreifuss muscular dystrophy; myoclonic dystonia 26; INTERACTS WITH 2-palmitoylglycerol; benzo[a]pyrene; paracetamol
- C22orf23 [Search on AGR]
Homo sapiens ASSOCIATED WITH adenylosuccinase lyase deficiency; Emery-Dreifuss muscular dystrophy; myoclonic dystonia 26; INTERACTS WITH aristolochic acid A; benzo[a]pyrene; camptothecin
- Cimip4 [Search on AGR]
Homo sapiens ASSOCIATED WITH adenylosuccinase lyase deficiency; autosomal recessive chronic granulomatous disease 3; Emery-Dreifuss muscular dystrophy; FOUND IN sperm flagellum (ortholog); INTERACTS WITH benzo[a]pyrene; 1,2-dichloroethane (ortholog); 17beta-estradiol (ortholog)
- Emd [Search on AGR]
Rattus norvegicus Predicted to enable actin binding activity and beta-tubulin binding activity. Involved in nuclear membrane reassembly. Located in nuclear envelope. Human ortholog(s) of this gene implicated in Emery-Dreifuss muscular dystrophy; X-linked Emery-Dreifuss muscular dystrophy 1; and dilated cardiomyopathy. Orthologous to human EMD (emerin); PARTICIPATES IN arrhythmogenic right ventricular cardiomyopathy pathway; dilated cardiomyopathy pathway; hypertrophic cardiomyopathy pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
- Listericin [Search on AGR]
Drosophila melanogaster Listericin (Listericin) encodes an antibacterial protein whose induction is cooperatively regulated by the product of PGRP-LE and the JAK-STAT pathway.