Ache [Search on AGR]
Mus musculus PHENOTYPE: Homozygous mutants show retarded postnatal development, tremors, impaired righting response, delayed maturation of external ear, failure of eyelids to open, and die by 3-wk. of age. Mutants are highly sensitive to butyrylcholinesterase inhibitor toxicity. [provided by MGI curators]
Cd40 [Search on AGR]
Rattus norvegicus Enables antigen binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to cobalamin; and response to type II interferon. Located in several cellular components, including cell surface; neuronal cell body; and varicosity. Used to study several diseases, including Ehrlich tumor carcinoma; artery disease (multiple); colitis; membranous glomerulonephritis; and obesity. Biomarker of asthma; atherosclerosis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule); PARTICIPATES IN allograft rejection pathway; asthma pathway; autoimmune thyroiditis pathway; INTERACTS WITH (+)-pilocarpine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine.
Cd40lg [Search on AGR]
Rattus norvegicus Enables CD40 receptor binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of dendritic cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in several cellular components, including cell body; cell surface; and extracellular space. Used to study Ehrlich tumor carcinoma; artery disease (multiple); autoimmune disease (multiple); thrombosis; and vitamin B12 deficiency. Biomarker of atherosclerosis; coronary artery disease; perinatal necrotizing enterocolitis; periodontal disease; and pulmonary hypertension. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); combined T cell and B cell immunodeficiency (multiple); hematologic cancer (multiple); and lupus nephritis. Orthologous to human CD40LG (CD40 ligand); PARTICIPATES IN interleukin-4 signaling pathway; obesity pathway; allograft rejection pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 4-aminopyridine.