Contributes to microtubule severing ATPase activity. Involved in microtubule depolymerization. Part of katanin complex. Expressed in amphid neurons; inner labial neurons; outer labial neurons; and phasmid neurons.
Contributes to microtubule severing ATPase activity. Involved in microtubule depolymerization. Part of katanin complex. Human ortholog(s) of this gene implicated in lissencephaly 6. Is an ortholog of human KATNB1 (katanin regulatory subunit B1).
Enables several functions, including ATP binding activity; MATH domain binding activity; and microtubule severing ATPase activity. Involved in several processes, including cytoskeleton organization; female meiotic nuclear division; and negative regulation of meiotic spindle elongation. Located in meiotic spindle pole and nucleus. Part of chromatin and katanin complex. Expressed in ciliated neurons; germ line; and head neurons. Is an ortholog of human KATNA1 (katanin catalytic subunit A1) and KATNAL1 (katanin catalytic subunit A1 like 1).
Contributes to microtubule severing ATPase activity. Involved in embryo development; meiotic spindle organization; and microtubule depolymerization. Located in cytoplasm; nucleus; and spindle pole. Part of katanin complex.
mei-217 (mei-217) is encoded on the same mRNA as the product of mei-218. The products of mei-217 and mei-218 interact physically and are involved in meiotic recombination.
meiotic 218 (mei-218) is encoded on the same mRNA as the product of mei-217. The products of mei-217 and mei-218 interact physically and are involved in meiotic recombination.
recombination-defective (rec) interacts with other Mini-Chromosome Maintenance (MCM)-related proteins (encoded by mei-217 and mei-218) to make meiotic crossovers.
meiotic 9 (mei-9) encodes the catalytic subunit of the Mei-9-Ercc1 structure-selective endonuclease that functions in nucleotide excision repair. The products of mei-9 and Ercc1 interact with the product of mus312 to generate meiotic crossovers.
Enables POZ domain binding activity. Involved in cell development; protein catabolic process; and protein polyubiquitination. Part of Cul3-RING ubiquitin ligase complex. Expressed in head; linker cell; and tail. Human ortholog(s) of this gene implicated in pseudohypoaldosteronism. Is an ortholog of human CUL3 (cullin 3).
Predicted to enable microtubule binding activity. Is an ortholog of C. elegans mei-2. In C. elegans, mei-2 is involved in embryo development; meiotic spindle organization; and microtubule depolymerization.