gex-2 [Browse genome (BioProject PRJNA13758)] [Search on AGR]
Caenorhabditis elegans Predicted to enable RNA 7-methylguanosine cap binding activity. Involved in several processes, including embryonic body morphogenesis; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in cell junction. Part of SCAR complex. Human ortholog(s) of this gene implicated in several diseases, including Schaaf-Yang syndrome; autism spectrum disorder; and epilepsy (multiple). Is an ortholog of human CYFIP1 (cytoplasmic FMR1 interacting protein 1) and CYFIP2 (cytoplasmic FMR1 interacting protein 2).
Sulf2 [Search on AGR]
Homo sapiens Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Magel2 [Search on AGR]
Rattus norvegicus Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; protein K63-linked ubiquitination; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within positive regulation of actin nucleation. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; bisphenol A.