VCAN-AS1

Homo sapiens

ASSOCIATED WITH fundus dystrophy; genetic disease; Hyaloideoretinal Degeneration of Wagner; INTERACTS WITH aristolochic acid A; doxorubicin

Helz

Homo sapiens

HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

cos

Drosophila melanogaster

costa (cos) encodes a kinesin-like protein and a key component in the Hedgehog (Hh) pathway that is involved in pattern formation and growth control. It forms a complex with the product of fu to restrict the activity of the Hh pathway transcription factor encoded by ci.

Vcan

Homo sapiens

This gene is a member of the aggrecan/versican proteoglycan family. The protein encoded is a large chondroitin sulfate proteoglycan and is a major component of the extracellular matrix. This protein is involved in cell adhesion, proliferation, proliferation, migration and angiogenesis and plays a central role in tissue morphogenesis and maintenance. Mutations in this gene are the cause of Wagner syndrome type 1. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]