sxc

Drosophila melanogaster

super sex combs (sxc) is a polycomb group gene that encodes a O-GlcNAc transferase involved in epigenetic gene silencing.

Psc

Drosophila melanogaster

Posterior sex combs (Psc) was originally identified as a member of the Polycomb group of genes that regulate gene expression through epigenetic marks.

Asx

Drosophila melanogaster

Additional sex combs (Asx) encodes a chromatin binding protein with deubiquitination activity of the product of His2A. It genetically interacts with Pc and sxc and represses homeotic genes transcription. It contributes to antennal development and embryonic cell cycle.

mxc

Drosophila melanogaster

multi sex combs (mxc) encodes a Cylin E/Cdk2 substrate and molecular scaffold that is necessary for assembly of the histone locus body, which is a nuclear body associated with replication dependent histone gene clusters that contains factors necessary for the transcription and processing of histone mRNA.

Scr

Drosophila melanogaster

Sex combs reduced (Scr) is a member of the Antennapedia complex (ANT-C), one of two Hox gene complexes. Products of members of the ANT-C control the identity of segments that contribute to the head and the anterior thorax. Scr is expressed in the embryonic labial and first thoracic segments. In the absence of its expression the first prothoracic segment is transformed to a second mesothoracic identity and the labial palps to maxillary.

lin-39

Caenorhabditis elegans

Enables cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of DNA-templated transcription; positive regulation of developmental process; and regulation of cell division. Located in nucleus. Expressed in several structures, including hypodermis; male-specific anatomical entity; neurons; somatic nervous system; and ventral cord blast cell. Is an ortholog of human HOXA5 (homeobox A5).

mes-6

Caenorhabditis elegans

Predicted to contribute to nucleosome binding activity. Involved in regulation of gene expression. Part of PcG protein complex and nucleosome. Expressed in Z2; Z3; germ line; intestinal cell; and oocyte. Is an ortholog of human EED (embryonic ectoderm development).

spat-3

Caenorhabditis elegans

Enables histone ubiquitin ligase activity. Involved in several processes, including negative regulation of gene expression, epigenetic; negative regulation of vulval development; and nematode male tail tip morphogenesis. Predicted to be part of PcG protein complex and ubiquitin ligase complex. Expressed in several structures, including AIYL; AIYR; SMDDL; and SMDDR. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome and pancreatic ductal carcinoma. Is an ortholog of human RING1 (ring finger protein 1) and RNF2 (ring finger protein 2).

Asxl1

Homo sapiens

This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

nlp-88

Caenorhabditis elegans

Predicted to be involved in neuropeptide signaling pathway.