K06A9.1

Caenorhabditis elegans

Predicted to be located in membrane.

rpoa-2

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Located in nucleolus. Expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Is an ortholog of human POLR1B (RNA polymerase I subunit B).

rpac-19

Caenorhabditis elegans

Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study obesity. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Is an ortholog of human POLR1D (RNA polymerase I and III subunit D).

rpac-40

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Is an ortholog of human POLR1C (RNA polymerase I and III subunit C).

CRE12331

Caenorhabditis remanei

Is predicted to encode a protein with the following domains: Treacle protein domain and Treacher Collins syndrome protein Treacle. Is an ortholog of C. elegans H06H21.11.

F29A7.6

Caenorhabditis elegans

Predicted to be involved in maturation of 5.8S rRNA. Expressed widely. Is an ortholog of human MPHOSPH6 (M-phase phosphoprotein 6).

bus-6

Caenorhabditis elegans

Expressed in intestine.

mls-2

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment of mitotic spindle orientation; neuron differentiation involved in amphid sensory organ development; and regulation of cell differentiation. Located in nucleus. Expressed in several structures, including AB lineage cell; AWC-ON; M.dla; head; and somatic nervous system. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Is an ortholog of human HMX1 (H6 family homeobox 1).

gtl-1

Caenorhabditis elegans

Predicted to enable monoatomic cation channel activity. Involved in defecation. Predicted to be located in plasma membrane. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis-parkinsonism/dementia complex 1; cataract; and congenital stationary night blindness 1C. Is an ortholog of human TRPM1 (transient receptor potential cation channel subfamily M member 1); TRPM3 (transient receptor potential cation channel subfamily M member 3); and TRPM7 (transient receptor potential cation channel subfamily M member 7).

cpna-1

Caenorhabditis elegans

Enables phosphatase binding activity and protein-macromolecule adaptor activity. Involved in positive regulation of sarcomere organization. Located in M band and striated muscle dense body. Expressed in body wall musculature.