K06A9.1

Caenorhabditis elegans

Predicted to be located in membrane.

rpoa-2

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Located in nucleolus. Expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Is an ortholog of human POLR1B (RNA polymerase I subunit B).

rpac-19

Caenorhabditis elegans

Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study obesity. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Is an ortholog of human POLR1D (RNA polymerase I and III subunit D).

rpac-40

Caenorhabditis elegans

Predicted to enable DNA-directed 5'-3' RNA polymerase activity and protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase I and transcription by RNA polymerase III. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 3 and hypomyelinating leukodystrophy 11. Is an ortholog of human POLR1C (RNA polymerase I and III subunit C).

CRE12331

Caenorhabditis remanei

Is predicted to encode a protein with the following domains: Treacle protein domain and Treacher Collins syndrome protein Treacle. Is an ortholog of C. elegans H06H21.11.

Tcof1

Rattus norvegicus

Predicted to enable protein heterodimerization activity; protein-macromolecule adaptor activity; and scaffold protein binding activity. Predicted to be involved in mesenchymal cell differentiation; nucleolar large rRNA transcription by RNA polymerase I; and regulation of translation. Predicted to be located in cytosol; fibrillar center; and nucleoplasm. Predicted to be active in nucleolus. Human ortholog(s) of this gene implicated in Treacher Collins syndrome and Treacher Collins syndrome 1. Orthologous to human TCOF1 (treacle ribosome biogenesis factor 1); PARTICIPATES IN ribosome biogenesis pathway; INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; amphetamine.

Polr1C

Homo sapiens

The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Tcof1

Homo sapiens

This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Polr1B

Rattus norvegicus

Contributes to DNA-directed 5'-3' RNA polymerase activity. Involved in rRNA transcription. Part of RNA polymerase I complex. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Orthologous to human POLR1B (RNA polymerase I subunit B); PARTICIPATES IN RNA polymerase I transcription pathway; purine metabolic pathway; pyrimidine metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.

Polr1D

Homo sapiens

The protein encoded by this gene is a component of the RNA polymerase I and RNA polymerase III complexes, which function in the synthesis of ribosomal RNA precursors and small RNAs, respectively. Mutations in this gene are a cause of Treacher Collins syndrome (TCS), a craniofacial development disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2011]