K06A9.1

Caenorhabditis elegans

Predicted to be located in membrane.

H42

Mus musculus

PHENOTYPE: This minor histocompatibility antigen is recognized by rejection of skin grafts between C57BL/10 and B10.FS-a (congenic for B2m, H3, and H13). The a allele occurs in C57BL/10; the b allele occurs in B10.FS-a and presumably in FS/SnEi. [provided by MGI curators]

clos

Drosophila melanogaster

closca (clos) encodes a protein that is required, together with the products of fs(1)N and fs(1)M3, for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation.

rpoa-2

Caenorhabditis elegans

Predicted to enable DNA binding activity; DNA-directed 5'-3' RNA polymerase activity; and ribonucleoside binding activity. Predicted to contribute to RNA polymerase I activity. Predicted to be involved in transcription by RNA polymerase I. Located in nucleolus. Expressed in several structures, including intestine. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 4. Is an ortholog of human POLR1B (RNA polymerase I subunit B).

fs(1)M3

Drosophila melanogaster

female sterile (1) M3 (fs(1)M3) encodes a protein that is required, along with the products of fs(1)N and clos, for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation.

fs(1)N

Drosophila melanogaster

female sterile (1) Nasrat (fs(1)N) encodes encodes a protein that is required, along with the products of fs(1)M3 and clos, for their accumulation at the vitelline membrane and function in vitelline membrane integrity and Torso receptor activation.

fs(1)h

Drosophila melanogaster

female sterile (1) homeotic (fs(1)h) encodes a Bromodomain and Extra-Terminal domain (BET) family of protein, characterized by the presence of two tandem bromodomains and an extra-terminal (ET) domain. BET proteins can bind acetylated lysine residues in histones and regulate transcription. The proteins encoded by fs(1)h and human BRD2 possess protein kinase activity.

fs(1)Yb

Drosophila melanogaster

female sterile (1) Yb (fs(1)Yb) encodes a protein involved in maintenance of the germ-line stem cell population during oogenesis.

rpac-19

Caenorhabditis elegans

Predicted to enable protein dimerization activity. Predicted to contribute to RNA polymerase I activity and RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III and transcription elongation by RNA polymerase I. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex and RNA polymerase III complex. Used to study obesity. Human ortholog(s) of this gene implicated in Treacher Collins syndrome 2. Is an ortholog of human POLR1D (RNA polymerase I and III subunit D).

Fs

Drosophila melanogaster

Follistatin (Fs) encodes a secreted protein that inhibits activin and decapentaplegic receptor signaling pathways but enhances signaling mediated by the Activin-like protein encoded by daw.