chw-1

Caenorhabditis elegans

Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Involved in establishment or maintenance of cell polarity and vulval development. Predicted to be located in plasma membrane. Expressed in several structures, including P3.pa; P3.pp; P4.pa; P4.pp; and P8.pa. Is an ortholog of human RHOU (ras homolog family member U).

M04D5.1

Caenorhabditis elegans

Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human P4HB (prolyl 4-hydroxylase subunit beta); PDIA2 (protein disulfide isomerase family A member 2); and PDILT (protein disulfide isomerase like, testis expressed).

nlp-26

Caenorhabditis elegans

Predicted to be involved in neuropeptide signaling pathway. Expressed in several structures, including P2.p; P3.pa; P3.pp; P4.pa; and P4.pp.

let-765

Caenorhabditis elegans

Predicted to enable chromatin DNA binding activity and histone binding activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of Ras protein signal transduction; and vulval cell fate specification. Located in nucleus. Expressed in several structures, including P3.pa; P3.pp; P4.pa; P5.ppp; and P7.paa. Is an ortholog of human SBNO1 (strawberry notch homolog 1).

D1081.19

Caenorhabditis elegans

Is affected by several genes including nuo-6; ash-2; and isp-1 based on RNA-seq and microarray studies. Is affected by six chemicals including Atrazine; cadmium; and fluoranthene based on microarray studies. Is predicted to encode a protein with the following domains: Peptidase S1, PA clan, chymotrypsin-like fold; Peptidase S1, PA clan; Nematode trypsin-6-like family; and Chymotrypsin family Peptidase-S1.

D1081.3

Caenorhabditis elegans

Enriched in male based on RNA-seq studies. Is affected by several genes including cyc-1; mut-16; and atfs-1 based on microarray; tiling array; and RNA-seq studies. Is affected by eight chemicals including methylmercuric chloride; manganese chloride; and stavudine based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Peptidase S1, PA clan, chymotrypsin-like fold; Peptidase S1, PA clan; Nematode trypsin-6-like family; and Chymotrypsin family Peptidase-S1.

T07F12.2

Caenorhabditis elegans

Enriched in several structures, including ASH; PVR; germ line; intestine; and oocyte based on RNA-seq; single-cell RNA-seq; and microarray studies. Is affected by several genes including nuo-6; ptl-1; and isp-1 based on microarray and RNA-seq studies. Is affected by five chemicals including rotenone; Zidovudine; and paraquat based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: PA domain and PA domain superfamily. Is an ortholog of human PRADC1 (protease associated domain containing 1).

lin-36

Caenorhabditis elegans

Predicted to enable DNA binding activity and metal ion binding activity. Involved in embryonic digestive tract morphogenesis. Predicted to be located in nucleus. Expressed in several structures, including P3.pa; P5.ppp; P7.paa; neurons; and vulval cell.

try-13

Caenorhabditis elegans

Enriched in germ line; neurons; and in male based on proteomic; tiling array; RNA-seq; and single-cell RNA-seq studies. Is affected by several genes including ets-4; csr-1; and hsf-1 based on microarray; tiling array; and RNA-seq studies. Is affected by twelve chemicals including multi-walled carbon nanotube; Alovudine; and stavudine based on RNA-seq and microarray studies. Is predicted to encode a protein with the following domains: Peptidase S1, PA clan, chymotrypsin-like fold; Peptidase S1, PA clan; Nematode trypsin-6-like family; and Chymotrypsin family Peptidase-S1.

try-12

Caenorhabditis elegans

Enriched in Z1.p; Z4.a; male distal tip cell; neurons; and somatic gonad precursor based on microarray; tiling array; and RNA-seq studies. Is affected by several genes including cyc-1; nuo-6; and cua-1 based on microarray and RNA-seq studies. Is affected by eleven chemicals including methylmercuric chloride; rotenone; and rifampin based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: Peptidase S1, PA clan, chymotrypsin-like fold; Peptidase S1, PA clan; Nematode trypsin-6-like family; and Chymotrypsin family Peptidase-S1.