Sgpp1 [Search on AGR]
Homo sapiens Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid metabolite that regulates diverse biologic processes. SGPP1 catalyzes the degradation of S1P via salvage and recycling of sphingosine into long-chain ceramides (Mandala et al., 2000 [PubMed 10859351]; Le Stunff et al., 2007 [PubMed 17895250]).[supplied by OMIM, Jun 2009]
Tpe1 [Search on AGR]
Mus musculus PHENOTYPE: This locus controls electrophoretic variation of a protein in tears. A co-dominant fast band is seen in C3H/He, CBA/N, IC/Le, KK, SWM/MS, WB/Re and WC/Re; a co-dominant slow band in DBA/1, DBA/2, C57L, NZB, NZW and SM; and a recessive null allele (no band) in BALB/c, A/He, AKR, CL/Fr, DDD and NC. [provided by MGI curators]
Coq3 [Search on AGR]
Homo sapiens Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008]