epg-8

Caenorhabditis elegans

Predicted to enable phosphatidylinositol 3-kinase regulator activity and protein-membrane adaptor activity. Involved in macroautophagy; positive regulation of autophagy; and positive regulation of embryonic development. Located in cytoplasm. Expressed in neurons and pharyngeal muscle cell.

VPS30

Saccharomyces cerevisiae

Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy, Complex II is required for vacuolar protein sorting; required for overflow degradation of misfolded proteins when ERAD is saturated; C-terminus has novel globular fold essential for autophagy through the targeting of the PI3-kinase complex I to the pre-autophagosomal structure; ortholog of higher eukaryote gene Beclin 1; human BECN1 can complement yeast null mutant

Ambra1

Rattus norvegicus

Predicted to enable enzyme binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in cellular response to starvation; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of autophagy. Predicted to be located in axoneme; cytosol; and phagocytic vesicle. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex. Predicted to be active in cytoskeleton; mitochondrion; and nucleus. Orthologous to human AMBRA1 (autophagy and beclin 1 regulator 1); PARTICIPATES IN inositol metabolic pathway; mitochondrial autophagy pathway; phosphoinositide metabolic pathway; INTERACTS WITH ammonium chloride; atrazine; bisphenol A.

Rubcnl

Homo sapiens

This gene encodes a cysteine-rich protein that contains a putative zinc-RING and/or ribbon domain. The encoded protein is related to Run domain Beclin-1-interacting and cysteine-rich domain-containing protein, which plays a role in endocytic trafficking and autophagy. In cervical cancer cell lines, this gene is expressed at low levels and may function as a tumor suppressor. Promoter hypermethylation of this gene is observed in cervical cancer cell lines and tissue derived from human patients. [provided by RefSeq, Mar 2017]

Becn1

Rattus norvegicus

Enables ubiquitin protein ligase binding activity. Involved in several processes, including intracellular signaling cassette; regulation of apoptotic process; and regulation of organelle organization. Located in dendrite and trans-Golgi network. Used to study brain ischemia and middle cerebral artery infarction. Biomarker of several diseases, including Barrett's esophagus; acute necrotizing pancreatitis; artery disease (multiple); brain disease (multiple); and neuropathy (multiple). Human ortholog(s) of this gene implicated in Machado-Joseph disease and breast cancer. Orthologous to human BECN1 (beclin 1); PARTICIPATES IN autophagy pathway; inositol metabolic pathway; mitochondrial autophagy pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (-)-anisomycin.

Becn2

Rattus norvegicus

Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Predicted to be involved in cellular response to nitrogen starvation; late endosome to vacuole transport; and macroautophagy. Predicted to act upstream of or within several processes, including G protein-coupled receptor catabolic process; endosome to lysosome transport; and glucose homeostasis. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in phagophore assembly site. Orthologous to human BECN2 (beclin 2); INTERACTS WITH bisphenol A; ginsenoside Rg2 (ortholog).

bec-1

Caenorhabditis elegans

Predicted to enable phosphatidylinositol 3-kinase binding activity and protein-macromolecule adaptor activity. Involved in several processes, including determination of adult lifespan; gamete generation; and nematode male tail tip morphogenesis. Located in cytoplasmic vesicle and nucleus. Expressed in several structures, including intestine; nervous system; pharynx; tail; and vulva. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Barrett's esophagus; Machado-Joseph disease; and adenocarcinoma (multiple). Is an ortholog of human BECN1 (beclin 1).