Fhe

Mus musculus

PHENOTYPE: This locus controls development of erythroblastosis induced by helper virus component of Friend NB-tropic virus. The r allele determines resistance in C57BL/6 and B10.D2 strains; the s allele determines susceptibility in BALB/c. F1 mice are resistant. [provided by MGI curators]

Fv4

Mus musculus

PHENOTYPE: Strain G and wild mice have a dominant resistant allele to AKR and NB-tropic, but not amphotropic, leukemia viruses. DNA of these mice hybridizes to ecotropic env-gene probes suggesting resistance via a gp70 related protein binding to exogenous virus. DBA/2, BALB/c and most inbreds are susceptible. [provided by MGI curators]

Fv6

Mus musculus

PHENOTYPE: This locus controls susceptibility to early erythroleukemia induction by helper virus-independent NB-tropic Friend leukemia virus. BALB/c, NFS and C3H/He carry the susceptibility (s) allele; DBA/2, DBA/1, C57BL/6, C57BL/10, C57L, CBA/N and AKR/N carry the dominant resistant ( r) allele. [provided by MGI curators]

Apaf1

Homo sapiens

This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]