Ssdp

Drosophila melanogaster

Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes.

AIM18

Saccharomyces cerevisiae

Hemoprotein; protein of unknown function that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

adh-5

Caenorhabditis elegans

Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including AMED syndrome; alcohol dependence; and late onset Parkinson's disease. Is an ortholog of human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide).

AIM46

Saccharomyces cerevisiae

Hemoprotein; protein of unknown function that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

Chi

Drosophila melanogaster

Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance.

ap

Drosophila melanogaster

apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding.

Mnd1

Homo sapiens

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

Adh5

Rattus norvegicus

Enables alcohol dehydrogenase (NAD+) activity. Involved in ethanol catabolic process. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Used to study alcohol use disorder. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in AMED syndrome and asthma. Orthologous to human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide); PARTICIPATES IN fatty acid metabolic pathway; gluconeogenesis pathway; glycolysis pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

pygo

Drosophila melanogaster

pygopus (pygo) encodes a key nuclear component of the Wnt signaling pathway. It facilitates the recruitment of the product of arm to Wnt-responsive genes by interacting with the transcription cofactor encoded by Chi. It also binds the product of lgs and the methylated tail of the product of His3. Together, they associate with the product of arm in a process that may function as a transition from gene silence to Wnt-induced transcription.