Ssdp

Drosophila melanogaster

Sequence-specific single-stranded DNA-binding protein (Ssdp) encodes a DNA binding protein. It has been proposed to be an additional component of ap/Chi transcriptional complexes because it interacts with the product of Chi and lack of Ssdp produces defects similar to ap or Chi mutant phenotypes.

AIM18

Saccharomyces cerevisiae

Hemoprotein; protein of unknown function that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

adh-5

Caenorhabditis elegans

Predicted to enable S-(hydroxymethyl)glutathione dehydrogenase [NAD(P)+] activity; alcohol dehydrogenase (NAD+) activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in several diseases, including AMED syndrome; alcohol dependence; and late onset Parkinson's disease. Is an ortholog of human ADH5 (alcohol dehydrogenase 5 (class III), chi polypeptide).

AIM46

Saccharomyces cerevisiae

Hemoprotein; protein of unknown function that localizes to the mitochondrial inner mnembrane; null mutant displays elevated frequency of mitochondrial genome loss; contains a chalcone isomerase (CHI) domain, a predicted N-terminal transmembrane domain and an N-terminal mitochondrial targeting sequence; lacks CHI catalytic activity

Chi

Drosophila melanogaster

Chip (Chi) encodes a transcriptional co-factor that regulates gene expression. It contributes to the regulation of Notch signaling, leg development and axon guidance.

Slc25a37

Homo sapiens

SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]

ap

Drosophila melanogaster

apterous (ap) encodes a transcription factor that functions in a tetramer consisting of a dimer of the product of Chi and two monomers ODF the product of ap. It contributes to the dorsal identity of wing cells, muscle development, juvenile hormone production and neuronal path finding.

Abcb5

Homo sapiens

ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

Mnd1

Homo sapiens

The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]

Rab8b

Homo sapiens

RAB proteins, like RAB8B, are low molecular mass monomeric GTPases that localize on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB proteins function in intracellular vesicle transport by aiding in the docking and/or fusion of vesicles with their target membranes (summary by Chen et al., 1997 [PubMed 9030196]).[supplied by OMIM, Nov 2010]