- Nrk [Search on AGR]
Drosophila melanogaster Neurospecific receptor kinase (Nrk) encodes a receptor tyrosine kinase that is expressed in the developing nervous system and regulates axon pathfinding and rhabdomere elongation. It interacts genetically with Dys and Dg.
- SP2353 [Search on AGR]
Drosophila melanogaster SP2353 (SP2353) encodes a EGF-like- and LamininG-domain-containing protein. It interacts genetically with Dg, which encodes a extracellular matrix receptor. It regulates muscle homeostasis, rhabdomere differentiation and innate immune response.
- rt [Search on AGR]
Drosophila melanogaster rotated abdomen (rt) encodes a protein that transfers a mannose to the Ser/Thr residues of the product of Dg, via forming an heterodimer with the product of tw. Its roles include myogenesis, muscle architecture and cell adhesion.
- Dg [Search on AGR]
Drosophila melanogaster Dystroglycan (Dg) encodes a major non-integrin extracellular matrix (ECM) receptor that connects the ECM to the actin cytoskeleton. It regulates animal survival and temperature preference, muscle integrity, myotendinous and neuromuscular junction formation and function, nervous system development, axon pathfinding, rhabdomere differentiation, neuronal stem cell division and epithelial polarity.
- Dys [Search on AGR]
Drosophila melanogaster Dystrophin (Dys) encodes a cytoplasmic protein that connects the actin cytoskeleton to the extracellular matrix via the receptor encoded by Dg. In addition, the product of Dys serves as a cytoplasmic scaffold for the membrane localization of different signaling factors, including nanos, which regulates expression of miRNAs to adapt cellular homeostasis to changes induced by stress and dystrophy.
- Pomk [Search on AGR]
Homo sapiens This gene encodes a protein that may be involved in the presentation of the laminin-binding O-linked carbohydrate chain of alpha-dystroglycan (a-DG), which forms transmembrane linkages between the extracellular matrix and the exoskeleton. Some pathogens use this O-linked carbohydrate unit for host entry. Loss of function compound heterozygous mutations in this gene were found in a human patient affected by the Walker-Warburg syndrome (WWS) phenotype. Mice lacking this gene contain misplaced neurons (heterotopia) in some regions of the brain, possibly from defects in neuronal migration. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]