Enables protein serine/threonine kinase activity and transcription coactivator binding activity. Involved in several processes, including apical protein localization; negative regulation of protein import into nucleus; and post-embryonic development. Located in apical plasma membrane and cytoplasm. Expressed in several structures, including excretory canal; hypodermis; intestine; spermatheca; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer. Is an ortholog of human LATS1 (large tumor suppressor kinase 1).
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and protein kinase binding activity. Involved in establishment of cell polarity and positive regulation of transcription by RNA polymerase II. Located in axoneme; ciliary base; and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including excretory system; hermaphrodite gonad; pharyngeal muscle cell; tail hypodermis; and vulva. Human ortholog(s) of this gene implicated in colorectal cancer and uveal coloboma-cleft lip and palate-intellectual disability. Is an ortholog of human WWTR1 (WW domain containing transcription regulator 1) and YAP1 (Yes1 associated transcriptional regulator).
Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).