Enables calcium-activated potassium channel activity and outward rectifier potassium channel activity. Involved in positive regulation of neurotransmitter secretion and potassium ion transport. Located in axon. Expressed in amphid neurons; body wall musculature; motor neurons; nerve ring; and vulval muscle. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5; developmental and epileptic encephalopathy 14; and developmental and epileptic encephalopathy 57. Is an ortholog of human KCNT1 (potassium sodium-activated channel subfamily T member 1) and KCNT2 (potassium sodium-activated channel subfamily T member 2).
Enables calcium-activated potassium channel activity and voltage-gated potassium channel activity. Involved in several processes, including behavioral response to ethanol; nematode pharyngeal pumping; and sarcomere organization. Located in M band; striated muscle dense body; and synapse. Expressed in several structures, including AWC; body wall musculature; non-striated muscle; pharyngeal neurons; and somatic nervous system. Used to study Duchenne muscular dystrophy and alcohol use disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease; idiopathic generalized epilepsy; paroxysmal nonkinesigenic dyskinesia 3; and spermatogenic failure. Is an ortholog of human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
Enables transmembrane transporter binding activity. Located in neuron projection and striated muscle dense body. Expressed in body wall musculature; head mesodermal cell; muscle cell; neurons; and somatic nervous system.
Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).