Predicted to be involved in endoplasmic reticulum organization. Predicted to be located in endoplasmic reticulum. Is an ortholog of human PCNX2 (pecanex 2) and PCNX3 (pecanex 3).
Predicted to enable chromatin binding activity; histone H4K16 acetyltransferase activity; and transcription coregulator activity. Involved in cell fate specification; maintenance of left/right asymmetry; and positive regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MSL complex; NSL complex; and NuA4 histone acetyltransferase complex.
Predicted to enable endopeptidase activity. Involved in several processes, including apical protein localization; egg-laying behavior; and regulation of signal transduction. Located in perinuclear region of cytoplasm. Used to study Alzheimer's disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 3; Alzheimer's disease 4; Pick's disease; dilated cardiomyopathy (multiple); and hidradenitis suppurativa. Is an ortholog of human PSEN1 (presenilin 1) and PSEN2 (presenilin 2).
Predicted to enable metalloendopeptidase activity. Involved in several processes, including nematode male tail tip morphogenesis; positive regulation of transforming growth factor beta receptor signaling pathway; and vulval development. Located in cytoplasmic vesicle membrane and plasma membrane. Expressed in M lineage cell; hypodermis; intestinal cell; spermatheca; and vulva. Human ortholog(s) of this gene implicated in Alzheimer's disease 18; colorectal cancer; and reticulate acropigmentation of Kitamura. Is an ortholog of human ADAM10 (ADAM metallopeptidase domain 10).
Predicted to enable endopeptidase activity. Involved in Notch signaling pathway and positive regulation of germ cell proliferation. Predicted to be located in Golgi membrane and endoplasmic reticulum membrane. Predicted to be part of gamma-secretase complex.
Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of centrosome duplication; and regulation of vulval development. Located in axon and cytoplasm. Expressed in body wall musculature; gonad; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Is an ortholog of human FBXW7 (F-box and WD repeat domain containing 7).