jun-1

Caenorhabditis elegans

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of RNA splicing; and response to starvation. Located in nucleus. Expressed in several structures, including excretory cell; hermaphrodite gonad; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); gastrointestinal system cancer (multiple); and lymphoma (multiple). Is an ortholog of human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); JUNB (JunB proto-oncogene, AP-1 transcription factor subunit); and JUND (JunD proto-oncogene, AP-1 transcription factor subunit).

kgb-2

Caenorhabditis elegans

Predicted to enable JUN kinase activity. Predicted to be involved in JNK cascade. Predicted to be located in cytoplasm and nucleus.

Y54F10BM.13

Caenorhabditis elegans

Predicted to enable JUN kinase phosphatase activity. Predicted to be located in cytoplasm. Is an ortholog of human DUSP19 (dual specificity phosphatase 19).

glh-4

Caenorhabditis elegans

Enables JUN kinase binding activity. Involved in gamete generation and regulation of cell population proliferation. Located in P granule.

glh-3

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity and JUN kinase binding activity. Predicted to be involved in germ cell development. Located in P granule. Expressed in gonad. Is an ortholog of human DDX4 (DEAD-box helicase 4).

kgb-1

Caenorhabditis elegans

Enables DEAD/H-box RNA helicase binding activity; JUN kinase activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including gamete generation; response to stress; and response to toxic substance. Located in cytoplasm. Expressed in several structures, including excretory cell; germ line; gonad; nerve ring; and tail ganglion.

sek-6

Caenorhabditis elegans

Predicted to enable JUN kinase kinase activity. Predicted to be involved in MAPK cascade. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); invasive ductal carcinoma; and prostate carcinoma in situ. Is an ortholog of human MAP2K4 (mitogen-activated protein kinase kinase 4).

jnk-1

Caenorhabditis elegans

Enables JUN kinase activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of cellular response to manganese ion; and response to stress. Located in several cellular components, including axon; neuronal cell body; and nucleus. Expressed in AIYL; AIYR; and neurons. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; abdominal aortic aneurysm; carcinoma (multiple); and intestinal benign neoplasm (multiple). Is an ortholog of human MAPK10 (mitogen-activated protein kinase 10); MAPK8 (mitogen-activated protein kinase 8); and MAPK9 (mitogen-activated protein kinase 9).

vhp-1

Caenorhabditis elegans

Enables JUN kinase phosphatase activity and MAP kinase tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of MAPK cascade; regulation of defense response to bacterium; and regulation of protein localization to nucleus. Acts upstream of with a negative effect on protein catabolic process. Predicted to be located in cytoplasm and nucleus. Is an ortholog of human DUSP16 (dual specificity phosphatase 16) and DUSP8 (dual specificity phosphatase 8).

dli-1

Caenorhabditis elegans

Predicted to enable dynein heavy chain binding activity. Involved in regulation of dendrite morphogenesis and retrograde axonal transport. Located in microtubule plus-end and neuron projection. Expressed in ciliated neurons; hypodermis; and pharynx. Is an ortholog of human DYNC1LI2 (dynein cytoplasmic 1 light intermediate chain 2).