Predicted to enable G protein-coupled receptor binding activity and G protein-coupled receptor kinase activity. Involved in several processes, including positive regulation of egg-laying behavior; positive regulation of growth rate; and serotonin catabolic process. Expressed in neurons and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including opiate dependence; rheumatoid arthritis; and toxic shock syndrome. Is an ortholog of human GRK2 (G protein-coupled receptor kinase 2) and GRK3 (G protein-coupled receptor kinase 3).
Predicted to enable protein kinase activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Oguchi disease-2; essential hypertension; and rheumatoid arthritis. Is an ortholog of human GRK5 (G protein-coupled receptor kinase 5) and GRK6 (G protein-coupled receptor kinase 6).
Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).