pha-4

Caenorhabditis elegans

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of metabolic process; and response to sodium arsenite. Located in nucleus. Expressed in several structures, including arcade cell; enteric muscle; gonad; pharynx; and rectum. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); lung carcinoma (multiple); and type 2 diabetes mellitus. Is an ortholog of human FOXA1 (forkhead box A1) and FOXA2 (forkhead box A2).

fkh-5

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Expressed in head neurons.

fkh-3

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus.

fkh-2

Caenorhabditis elegans

Enables DNA-binding transcription factor activity. Involved in several processes, including neuron differentiation; non-motile cilium assembly; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including AWB; Daaa; body wall muscle cell from D lineage; head muscle; and somatic nervous system. Is an ortholog of human FOXG1 (forkhead box G1).

fkh-4

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus.

fkh-10

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in gonad and pharyngeal neurons. Is an ortholog of human FOXL3 (forkhead box L3) and FOXL3-OT1.

fkh-7

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in several structures, including intestine; neurons; pharynx; reproductive system; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); communication disorder (multiple); and tuberculosis (multiple). Is an ortholog of human FOXP2 (forkhead box P2).

fkh-6

Caenorhabditis elegans

Enables sequence-specific DNA binding activity. Involved in male germ-line sex determination and male gonad development. Predicted to be located in nucleus. Expressed in gonadal sheath cell; male gonad; somatic gonad precursor; spermatheca; and in male. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4 and otosclerosis 11. Is an ortholog of human FOXI2 (forkhead box I2) and FOXI3 (forkhead box I3).

fkh-8

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in anatomical structure morphogenesis; cell differentiation; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Expressed in neurons and in male. Human ortholog(s) of this gene implicated in several diseases, including lymphedema-distichiasis syndrome; obesity; and type 2 diabetes mellitus. Is an ortholog of human FOXC2 (forkhead box C2); FOXL3 (forkhead box L3); and FOXL3-OT1.

dnj-25

Caenorhabditis elegans

Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).