K08E5.6

Caenorhabditis elegans

Is affected by several genes including smn-1; elt-7; and elt-2 based on RNA-seq studies.

F16G10.7

Caenorhabditis elegans

Enriched in NSM based on tiling array studies. Is affected by several genes including clk-1; elt-7; and elt-2 based on microarray and RNA-seq studies. Is predicted to encode a protein with the following domains: TRA-1 regulated protein R03H10.4 and TRA-1 regulated.

elt-2

Caenorhabditis elegans

Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and enzyme inhibitor activity. Involved in several processes, including defense response to other organism; determination of adult lifespan; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in several structures, including AWC; Ealaa; Ealp; Earaa; and intestine. Human ortholog(s) of this gene implicated in several diseases, including adenocarcinoma (multiple); artery disease (multiple); and congenital heart disease (multiple). Is an ortholog of human GATA4 (GATA binding protein 4); GATA5 (GATA binding protein 5); and GATA6 (GATA binding protein 6).

elt-7

Caenorhabditis elegans

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in endodermal cell fate determination. Located in nucleus. Expressed in E lineage cell.

ZK757.10

Caenorhabditis elegans

Enriched in neurons based on single-cell RNA-seq and RNA-seq studies. Is affected by several genes including elt-7; elt-2; and ilc-17.1 based on RNA-seq studies. Is predicted to encode a protein with the following domains: Snake toxin-like superfamily and Snake toxin and toxin-like protein.

F16G10.3

Caenorhabditis elegans

Is affected by rsr-2; mir-34; and elt-2 based on tiling array; microarray; and RNA-seq studies. Is predicted to encode a protein with the following domains: TRA-1 regulated protein R03H10.4 and TRA-1 regulated.

elt-3

Caenorhabditis elegans

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of transcription by RNA polymerase II; and response to stress. Located in nucleus. Expressed in several structures, including Caaaaa; Caaaap; hermaphrodite distal tip cell; hypodermal cell; and rectum.

elt-1

Caenorhabditis elegans

Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epidermal cell fate specification; regulation of transcription by RNA polymerase II; and spermatid development. Located in nucleus. Expressed in several structures, including V1L.a; V1R.a; V2L.a; seam cell; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including X-linked recessive disease (multiple); bone marrow cancer (multiple); and carcinoma (multiple). Is an ortholog of human GATA1 (GATA binding protein 1); GATA2 (GATA binding protein 2); and GATA3 (GATA binding protein 3).

vit-2

Caenorhabditis elegans

Predicted to enable lipid transporter activity. Predicted to be involved in lipid transport. Located in cytoplasmic vesicle; vesicle lumen; and yolk granule. Expressed in embryonic cell; gonad; intestine; oocyte; and pseudocoelom.

mtl-2

Caenorhabditis elegans

Enables cadmium ion binding activity and zinc ion binding activity. Involved in response to cadmium ion and response to heat. Expressed in intestinal cell and intestine.