akt-2

Caenorhabditis elegans

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and protein serine/threonine kinase activity. Involved in determination of adult lifespan; insulin receptor signaling pathway; and regulation of synaptic assembly at neuromuscular junction. Expressed in several structures, including excretory canal; neurons; pharynx; rectum; and vulva. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

akt-1

Caenorhabditis elegans

Enables calmodulin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; regulation of synaptic assembly at neuromuscular junction; and signal transduction. Located in axon; cytoplasmic side of plasma membrane; and somatodendritic compartment. Expressed in several structures, including excretory canal; neurons; pharynx; rectal gland cell; and ventral nerve cord. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); coronary artery disease (multiple); and glucose metabolism disease (multiple). Is an ortholog of human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3).

eak-3

Caenorhabditis elegans

Expressed in XXXL and XXXR.

pptr-1

Caenorhabditis elegans

Enables protein kinase binding activity and protein phosphatase activator activity. Contributes to protein serine/threonine phosphatase activity. Involved in several processes, including P granule assembly; determination of adult lifespan; and negative regulation of insulin receptor signaling pathway. Located in cytosol. Expressed in head; spermatheca; tail; and vulva. Used to study cancer. Is an ortholog of human PPP2R5E (protein phosphatase 2 regulatory subunit B'epsilon).

ist-1

Caenorhabditis elegans

Predicted to enable insulin receptor binding activity; phosphatidylinositol 3-kinase binding activity; and transmembrane receptor protein tyrosine kinase adaptor activity. Involved in dauer larval development; insulin receptor signaling pathway; and short-term memory.

ubc-19

Caenorhabditis elegans

Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in DNA damage response and protein polyubiquitination. Predicted to be located in nucleus. Is an ortholog of human AKTIP (AKT interacting protein).

W04B5.5

Caenorhabditis elegans

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and prostate cancer. Is an ortholog of human PDPK1 (3-phosphoinositide dependent protein kinase 1) and PDPK2P (3-phosphoinositide dependent protein kinase 2, pseudogene).

eak-4

Caenorhabditis elegans

Involved in dauer larval development. Located in plasma membrane. Expressed in XXXL and XXXR.

eak-6

Caenorhabditis elegans

Predicted to enable protein tyrosine phosphatase activity. Involved in dauer larval development. Located in plasma membrane. Expressed in XXXL and XXXR.

dnj-25

Caenorhabditis elegans

Predicted to enable clathrin binding activity. Involved in receptor-mediated endocytosis. Predicted to be located in cytoplasm; intracellular membrane-bounded organelle; and vesicle. Human ortholog(s) of this gene implicated in Parkinson's disease 19A. Is an ortholog of human DNAJC6 (DnaJ heat shock protein family (Hsp40) member C6).