Fastk

Mus musculus

PHENOTYPE: Mice homozygous for a null allele lack neutophil infiltration in a model of house dust mite induced allergic pulmonary inflammation. [provided by MGI curators]

Riox2

Mus musculus

PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced allergic response to house dust mites. [provided by MGI curators]

Ms4a4a

Mus musculus

PHENOTYPE: Mice homozygous for a knock-out allele show abnormal macrophage physiology and impaired eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite. [provided by MGI curators]

Clec10a

Mus musculus

PHENOTYPE: Homozygotes for a targeted null mutation exhibit elevated red blood cell counts but appear to be otherwise normal. Homozygosity for the p.Q236* mutation affects cell surface expression and leads to hypersensitivity to house dust mites. [provided by MGI curators]

Cd163

Mus musculus

PHENOTYPE: After hindlimb ischemia, mice homozygous for a knock-out allele exhibit increased muscle satellite cell proliferation, and enhanced skeletal muscle regeneration not limited to the site of injury. Knock-out mice also exhibit increased eosinophilic airway inflammation in house dust mite-challenged. [provided by MGI curators]

CLEC6A

Homo sapiens

The protein encoded by this gene is a type II membrane receptor with an extracellular C-type lectin-like domain fold. The extracellular portion binds structures with a high mannose content and has been shown to recognize several pathogens, including C. elegans, S. cerevisiae, M. tuberculosis, C. neoformans, and house dust mite. When stimulated, the encoded protein initiates signalling through the CARD9-Bcl10-Malt1 pathway, leading to the induction of cytokines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]